Session 94 - 12th CROI

Home

Session 94 Poster Abstracts
Microbicides: In Vitro and In Vivo
Thursday, 1:30 - 3:30 pm
Hall A

528	Evaluation of Nevirapine Permeability and Retention in HIV-1 Cell-Free and Budded Virions Renato Aguiar*¹, L Costa¹, H Pereira¹, R Brindeiro¹, and A Tanuri² ¹Federal Univ of Rio de Janeiro, Brazil and ²CDC, Atlanta, GA, USA
529	Inhibition of HIV-1 Infection by Fusion Inhibitors Expressed in Recombinant Lactic Acid Bacteria Daniel Boden*¹, O Pusch², L Tucker³, F Lee³, L Berry⁴, J P Patrick⁴, S Hanniffy⁵, J Wells⁵, B Ramratnam³, and M Markowitz⁴ ¹Aaron Diamond AIDS Res Ctr, Rockefeller Univ, New York, NY, USA; ²Med Univ of Vienna, Austria; ³Brown Univ Sch of Med, Providence, RI, USA; ⁴Aaron Diamond AIDS Res Ctr, Rockefeller Univ, New York, NY, USA; and ⁵Inst of Food Res, Norwich, UK
530	Development of a Lactobacillus-based Anti-ICAM-1 Antibody-delivery System for Use as an Anti-HIV Microbicide Caren Chancey*¹, J Seegers², and R Markham¹ ¹Johns Hopkins Univ, Bloomberg Sch of Publ Hlth, Baltimore, MD, USA and ²Erasmus Univ, Rotterdam, The Netherlands
531	Targeting anti-HIV-1 Peptides to Mucosal Surfaces with Commensal Probiotic Microbes Kenneth Henry*, S Adhya, S Rao, and D Hamer NIH, DHHS, Bethesda, MD, USA and NIH, DHHS, Bethesda, MD, USA
532	Relationships between Chemical Structure and Long-term Exposure Microbicidal Activity within a Series of HIV-1 Nonnucleoside Reverse Transcriptase Inhibitors of the DATA and DAPY Classes of Compounds Yven Van Herrewege*¹, P Lewi², J Michiels¹, K Andries³, M P de Béthune³, J Guillemont³, J Heeres², W Van den Broeck², H De Man², and G Vanham¹ ¹Inst of Tropical Med, Anwerp, Belgium; ²Janssen Pharma, Vosselaar, Belgium; and ³Tibotec, Mechelen, Belgium
533	In Vitro Evaluation of Nonoxynol 9 Toxicity: Lessons Learned from a Multicenter Comparison B Beer¹, G Doncel², F Krebs³, R Shattock⁴, P Fletcher⁴, R Buckheit⁵, K Watson⁵, C Duzzutti⁶, J Cummins¹, E Bromley⁷, N Richardson-Harmon⁷, L Pallansch¹, C Lackman-Smith¹, J Turpin⁸, and Patricia Reichelderfer*⁹ ¹Southern Res Inst, Frederick, MD, USA; ²Conrad, Norfolk, VA, USA; ³Drexel Univ Coll of Med, Philadelphia, PA, USA; ⁴St George's Hosp Med Sch, London, UK; ⁵Imquest BioSci, Frederick, MD, USA; ⁶CDC, Atlanta, GA, USA; ⁷BioStat Solutions, Mt Airy, MD, USA; ⁸NIAID, Bethesda, MD, USA; and ⁹NICHD, NIH, DHHS, Bethesda, MD, USA
534	Rectal Microbicide Gel Vehicle Distribution in the Lower Gastrointestinal Tract Using SPECT/CT and Direct Endoscopic Sampling Wasif Khan*, E Fuchs, T Parsons, R Bakshi, L Lee, C Silverthorn, and C Hendrix Johns Hopkins Univ Sch of Med, Baltimore, MD, USA
535	The Candidate Topical Microbicide PRO 2000/5 Inhibits HIV and HSV Infection following Vaginal Application: Results of a Double-blind Placebo-controlled Trial Marla Keller*¹, B Zerhouni-Layachi¹, N Cheshenko¹, M John¹, K Hogarty¹, A Kasowitz¹, C Goldberg¹, A Profy², M Klotman¹, and B Herold¹ ¹Mt Sinai Sch of Med, New York, NY, USA and ²Indevus Pharma, Inc, Lexington, MA, USA
536	Changes in Vaginal Flora Associated with Vaginal Microbicides: Cellulose Sulfate and Tenofovir Jessica Justman*^1,2, W El-Sadr³, K Mayer⁴, L Maslankowski⁵, C Hoesley⁶, J Absalon³, F Gai⁷, B Masse⁷, A Kwiecien⁸, J Rooney⁹, L Soto-Torres¹⁰, and HPTN 049 and 050 Protocol Teams ¹Bronx-Lebanon Hosp Ctr, NY, USA; ²Columbia Univ, New York, NY, USA; ³Harlem Hosp, Columbia Univ, New York, NY, USA; ⁴Miriam Hosp, Brown Univ, Providence, RI, USA; ⁵Univ of Pennsylvania, Philadelphia, USA; ⁶Univ of Alabama at Birmingham, USA; ⁷SCHARP/Fred Hutchinson Cancer Res Ctr, Seattle, WA, USA; ⁸Family Hlth Intl, Arlington, VA, USA; ⁹Gilead Sci, Foster City, CA, USA; and ¹⁰National Institute of Allergy and Infectious Diseases
537	A High Detection Rate of Cell-free Cervicovaginal HIV among HIV-infected Women Enrolled in a Vaginal Microbicide Trial in Northern Thailand Catherine McLean*¹, T Chaowanachan², T Evans-Strickfaden¹, J van de Wijgert³, P Kantipong⁴, P Kilmarx¹, W Aueaksorn², S Whitehead², T Siraprapasiri², C Hart¹, J Tappero², and L Markowitz¹ ¹CDC, Atlanta, GA, USA; ²Thailand Ministry of Publ Hlth-US CDC Collaboration, Nonthaburi; ³Population Council, New York, NY, USA; and ⁴Chiang Rai Hosp, Thailand
538	Evaluating the Potential Effect of Vaginal Microbicides to Reduce the Risk of Acquiring HIV in Female Sex Workers R Smith, E Bodine, David Wilson*, and S Blower Univ of California, Los Angeles, USA