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Session 112
Poster Abstracts
Pharmacology of NNRTIs
Wednesday, 1:30 - 3:30 pm
Hall A
650
Relevance of Drug Transporters and Drug Metabolism Enzymes to Nevirapine: Superimposition of Host Genotype
Andrew Owen*
1
, L Almond
1
, R Hartkoorn
1
, T Walsh
1
, M Youle
2
, A Bonington
3
, F Turner
2
, C Smith
2
, A M Garretti
2
, A Phillips
2
, O Janneh
1
, D Back
1
, and S Khoo
1
1
Liverpool Univ, UK;
2
Royal Free Hosp, London, UK; and
3
North Manchester Gen Hosp, UK
651
Pharmacogenetics of Efavirenz and Selective Pressure for Drug Resistance after Treatment Discontinuation: NWCS214, an Analysis of ACTG Studies A5095/A5097S
David W Haas*
1
, H Ribaudo
2
, R Kim
1
, C Tierney
2
, G Wilkinson
1
, R Gulick
3
, D Clifford
4
, C Marzolini
1
, and E Acosta
5
1
Vanderbilt Univ, Nashville, TN, USA;
2
Harvard Sch of Publ Hlth, Boston, MA, USA;
3
Weill Med Coll, Cornell Univ, New York, NY, USA;
4
Washington Univ Sch of Med, St Louis, MO, USA; and
5
Univ of Alabama at Birmingham, USA
652
G516T Polymorphism at the CYP2B6 Isoenzyme Significantly Influences Efavirenz Plasma Levels and the Risk of Neurological Symptoms
Sonia R-Novoa*, P Barreiro, A Rendon, J Gonzalez-Lahoz, and V Soriano
Hosp Carlos III, Madrid, Spain
653
Efavirenz Decreases Buprenorphine Exposure, but Is Not Associated with Opiate Withdrawal in Opioid Dependent Individuals
EF McCance-Katz*
1
, P Pade
1
, G Friedland
2
, G Morse
3
, D Moody
4
, and P Rainey
5
1
Richmond, Virginia;
2
New Haven, CT, USA;
3
Buffalo, NY, USA;
4
Salt Lake City, Utah; and
5
Seattle, Washington