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Session 147 Poster Abstracts
Clinical Studies of Hyperlipidemia, Fat Redistribution, and Glucose Metabolism
Thursday, 1:30 - 3:30 pm
Hall B


848    
Demographic and Clinical Characteristics of HIV+ Men and Women in the Study of Fat Redistribution and Metabolic Changes in HIV Infection (FRAM) Are Comparable to a National Probability Sample of HIV+ Patients in Medical Care in the U.S.
Phyllis Tien*1,2, C Benson3, A Zolopa5, C Grunfeld1,2, D Osmond4, and for the FRAM Study
1Univ of California, San Francisco, USA; 2San Francisco VA Med Ctr, CA, USA; 3Univ of Colorado, Denver, USA; 4Univ of California, San Francisco, USA; and 5Stanford Univ, CA, USA

Background:  The FRAM study assesses changes in and correlates of fat distribution and metabolism in HIV+ men and women compared to controls, using whole body magnetic resonance imaging and central laboratory analysis of metabolites. Carotid intima thickness is measured at follow up to determine associations with atherosclerosis. We present demographic and clinical characteristics of HIV+ participants in FRAM compared with a national probability sample of HIV+ patients in medical care in the United States in 1996 from the HIV Cost and Services Utilization Study (HCSUS).

Methods:  FRAM enrolled 825 HIV+ men and 350 HIV+ women randomly selected from clinics at 16 sites across the United States between June 2000 and September 2002. HCSUS analyzed 1996 cross-sectional data from an estimated 179,200 HIV+ men and 52,200 HIV+ women. The 95% confidence interval (CI) of the differences in percentages between FRAM and HCSUS were obtained.

Results:  Demographic characteristics between FRAM and HCSUS were not different. History of a clinical AIDS diagnosis was similar between FRAM men and HCSUS men (∆ 1%; 95% C.I. –4.3 to 6.2), but was greater in FRAM women than HCSUS women (∆16%; 95% C.I. 7.7 to 23.4). More FRAM women (∆15%; 95% C.I. 8.7 to 22.2) and men (∆6%; 95% C.I. 1.2 to 9.7) had a CD4 nadir < 200.

 

Characteristic

% Men (N)

% Women (N)

 

FRAM

HCSUS

FRAM

HCSUS

    Age*

 

 

 

 

        18–34

34.5 (283)

31 (55,552)

45.7 (159)

44 (22,968)

        35–49

54.8 (449)

56 (100,352)

48.0 (167)

48 (25,056)

        ≥50

10.7 (88)

12 (21,504)

6.3 (22)

8 (4,176)

 

 

 

 

 

    Race/Ethnicity

 

 

 

 

        White (non-Hispanic)

55 (454)

56 (100,352)

32.9 (115)

25 (13,050)

        African American

32.6 (269)

27 (48,384)

54.9 (192)

54 (28,188)

        Hispanic

10.1 (83)

14 (25,088)

8.6 (30)

18 (9,396)

        Other

2.3 (19)

3 (5,376)

3.7 (13)

2 (1,044)

 

 

 

 

 

    Risk Category

 

 

 

 

        IDU

18 (141)

23 (41,216)

27.3 (91)

28 (14,616)

        MSM

66 (516)

62 (111,104)

–

–

        Heterosexual Contact

9.9 (77)

9 (16,128)

56.2 (187)

51 (26,622)

        Other

6.1 (48)

6 (10,752)

16.5 (55)

20 (10,440)

*Adjusted to the HCSUS date of January 31, 1996

 

Conclusions:  Demographic and clinical characteristics of HIV+ men and women in FRAM are comparable to those reported in a national random sampling of HIV+ men and women in medical care in the United States. The representativeness of the FRAM sample increases its value as a resource for studies on fat distribution, metabolic changes, and atherosclerosis in HIV infection.

Keywords: fat distribution changes; glucose and insulin abnormalities; dyslipidemia