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Session 93
Poster Abstracts
Therapeutic Vaccination of Infected Patients
Friday, 1:30 - 3:30 pm
Hall A
524
Relative Effects of Therapeutic Immunization and Discontinuation of ART on HIV-1-specific CD4 and CD8 T Cells Producing Interferon-
G
in ART-treated Acutely Infected Subjects (QUEST Study)
Assia Samri*
1
, F Lampe
2
, S Kinloch-De Loes
2
, A Phillips
2
, L Perrin
3
, D Cooper
4
, L Goh
5
, B Hoen
6
, J Andersson
7
, A Sonnerborg
7
, D Smith
4
, C Tsoukas
8
, R El Habib
9
, G Theofan
10
, and B Autran
1
1
INSERM U543, Hosp Pitie-Salpetriere, Paris, France;
2
Royal Free and Univ Coll, London, UK;
3
Geneva Univ Hosp, Switzerland;
4
Natl Ctr in HIV Epidemiology and Clin Res, Univ of New South Wales, Sydney, Australia;
5
GlaxoSmithKline, Greenford, UK;
6
CMU Besancon, France;
7
Karolinska Inst, Stockholm, Sweden;
8
McGill Univ, Montreal, Canada;
9
Aventis Pasteur, Lyon, France; and
10
Immune Response Corp, Carlsbad, CA
525
A Phase II Randomized, Partially Blinded Trial of Antiretroviral Therapy, HIV-specific Immunizations, and IL-2 Cycles to Promote Efficient Control of Viral Replication (ACTG A5024)
J Michael Kilby*
1
, R Wang
2
, D Mildvan
3
, M Fischl
4
, J Santana-Bagur
5
, C Pilcher
6
, A Zolopa
7
, J Lawrence
8
, R Pollard
9
, R Bosch
2
, R Bucy
1
, R Mitsuyasu
10
, and The ACTG A5024 Protocol Team
1
Univ of Alabama at Birmingham, USA;
2
Harvard Univ, Boston, MA, USA;
3
Beth Israel Deaconess Med Ctr, Boston, MA, USA;
4
Univ of Miami, FL, USA;
5
Univ of Puerto Rico, San Juan;
6
Univ of North Carolina at Chapel Hill, USA;
7
Stanford Univ, CA, USA;
8
Univ of California, San Francisco, USA;
9
Univ of California, Davis, USA; and
10
Univ of California, Los Angeles, USA
526
Therapeutic Immunization with MVA.HIVA, a Recombinant Modified Vaccinia Virus Ankara / HIV-1 Gag Polyepitope Vaccine, in HIV-1-infected Subjects Receiving HAART
Lucy Dorrell*
1
, H Yang
1
, B Ondondo
1
, T Dong
1
, A Iversen
1
, K de Gleria
1
, A Suttill
2
, C Conlon
3
, T Rostron
1
, P Bowness
1
, S Rowland-Jones
1
, T Hanke
1
, and A McMichael
1
1
Weatherall Inst of Molecular Med, Oxford, UK;
2
Genito-Urinary Med, Oxford, UK; and
3
Univ of Oxford, UK
527
Immunogenicity of a Multi-epitope-based DNA Vaccine in HIV-1-infected Subjects Receiving Potent Antiretroviral Therapy
Cara Wilson*
1
, B Livingston
2
, S MaWhinney
1
, R Schooley
1
, J Forster
1
, M Anders
1
, N Blyveis
1
, J Scott
1
, M Newman
2
, and C Benson
1
1
Univ of Colorado Hlth Sci Ctr, Denver, USA and
2
Epimmune, San Diego, CA, USA