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Session 114
Poster Abstracts
Pharmacology: Entry Inhibitors and P-Glycoprotein
Friday, 1:30 - 3:30 pm
Hall A
663
A Novel Probe Drug Interaction Study to Investigate the Effect of Selected ARV Combinations on the Pharmacokinetics of a Single Oral Dose of UK-427,857 in HIV + ve Subjects
G Muirhead
1
, Anton Pozniak*
2
, B Gazzard
2
, M Nelson
2
, G Moyle
2
, C Ridgway
1
, R Taylor-Worth
1
, and D Russell
1
1
Pfizer Global Res and Devt, Sandwich, UK and
2
Chelsea and Westminster Hosp, London, UK
664
The Pharmacokinetic Interaction between the CCR5 Antagonist 873140 and Lopinavir/Ritonavir in Healthy Subjects
K Adkison, A Shachoy-Clark, L Fang, Y Lou, V Otto, M Berrey, and Stephen Piscitelli*
GlaxoSmithKline, Research Triangle Park, NC, USA
665
Correlation between P-glycorotein and CXCR4 on PBMC and CD4
+
Cells Isolated from HIV
+
Individuals
Becky Chandler*, S Khoo, M Detsikas, T Walsh, J Williams, D Back, and A Owen
Univ of Liverpool, UK
666
P-glycoprotein and MRP1 Interactions with Rifampicin
Ruben Hartkoorn*
1
, C Waitt
2
, M Chaponda
2
, G Davies
1
, B Chandler
1
, A Owen
1
, S Ward
3
, D Back
1
, and S Khoo
1
1
Univ of Liverpool, UK;
2
Royal Liverpool Univ Hosp, UK; and
3
Liverpool Sch of Tropical Med, UK
667
Racial Differences in Naive CD4
+
Lymphocyte P-glycoprotein Activity
Todd Hulgan*, J Donahue, R Kim, C Sutcliffe, B Lishawa, F Nicotera, R D'Aquila, S Raffanti, D Unutmaz, P Rebeiro, H Erdem, C Ingram, C Hawkins, and D Haas
Vanderbilt Univ, Nashville, TN, USA