Session 120 - 12th CROI

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Session 120 Poster Abstracts
Interactions among RTI Resistance Mutations
Wednesday, 1:30 - 3:30 pm
Hall A

698	The L74V Mutation in HIV-1 RT Diminishes Synthesis of Viral DNA in Real-time PCR and Impairs Rescue of ZDV-terminated DNA Synthesis Fernando Frankel*, D Turner, B Brenner, Y Quan, and M Wainberg McGill Univ AIDS Ctr, Lady Davis Inst, Jewish Gen Hosp, Montreal, Canada
699	Differential Effects of L74V and M184V Mutations on ATP-mediated Primer Unblocking in HIV-1 Reverse Transcriptase Carrying Thymidine Analog Resistance Mutations Luis R Miranda*¹ and M Götte² ¹Brigham & Women's Hosp, Harvard Med Sch, Boston, MA, USA and ²McGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, Canada
700	L74V Compensates for the Fitness Defect of K103N+L100I Christine E Koval* and L Demeter Univ of Rochester Sch of Med and Dentistry, NY, USA
701	Evidence by Cloning Analysis of the Rare Coexistence of the K65R/L74V Mutant in the Same HIV Genome P Colson¹, M Henry¹, C Tourres¹, I Ravaux², I Poizot-Martin³, and Catherine Tamalet*¹ ¹Timone Hospital, Marseille, France; ²Conception Hosp, Marseille, France; and ³Hosp St-Marguerite, Marseille, France
702	Clonal Analysis of HIV Quasi-species in Patients Harboring Plasma Genotype with K65R Mutation Associated with Thymidine Analogue Mutations or L74V Substitution Marc Wirden*¹, I Malet¹, A Derrache¹, A G Marcelin¹, B Roquebert¹, A Simon¹, M Kirstetter¹, L Morand-Joubert², and V Calvez¹ ¹Hosp Pitie-Salpetriere, Paris, France and ²Hosp St-Antoine, Paris, France
703	Effect of L74V or M184V, with Multiple Thymidine Analogue-associated Mutations, on Reverse Transcriptase Inhibitor Phenotypic Sensitivity Vinod Trivedi*¹, X Han¹, M Montes-Walters¹, M Filizzola², M Ferguson¹, and W O'Brien¹ ¹Univ of Texas Med Branch, Galveston, USA and ²La Casa Family Hlth Ctr at New Mexico, Santa Fe, USA
704	Contribution of Non-Thymidine Analog Nucleoside RT Inhibitor Associated Mutations to Phenotypic Hypersusceptibility to Efavirenz E Coakley and Neil Parkin* ViroLogic, Inc, South San Francisco, CA, USA