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Session 9
Oral Abstracts
Studies of Pathogenic and Non-Pathogenic Infection
Monday, 10 am - 12:30 pm
Room: Ballroom 5-6 |
Moderators: |
Jim Hoxie
Univ of Pennsylvania, Philadelphia, US
Jeffrey Lifson
NCI, SAIC, Frederick, MD, US
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| 10:00 am 35 |
Endemic Infection of Central Chimpanzees (Pan troglodytes troglodytes) by Simian Immunodeficiency Virus
Brandon Keele*1, F Heuverswyn2, Y Li1, E Bailes3, S Loul4, J Brookfield3, G Shaw1, P Sharp3, M Peeters2, and B Hahn1
1Univ of Alabama at Birmingham, US; 2Inst Res and Devt, Univ of Montpellier, France; 3Univ of Nottingham, UK; and 4Project Presica, Yaounde, Cameroon |
| 10:15 am 36 |
Severe Mucosal Depletion of CD4+ T Cells in Absence of Generalized Immune Activation during Non-pathogenic SIV-infected Sooty Mangabeys
Shari Gordon*1, J Engram1, J Milush2, R Dunham1, N Klatt1, E Strobert3, I Pandrea4, S Staprans1, D Sodora2, and G Silvestri1
1Emory Vaccine Ctr, Atlanta, GA, US; 2Univ of Texas Southwestern Med Ctr, Dallas, US; 3Yerkes Primate Ctr, Atlanta, GA, US; and 4Tulane Natl Primate Res Ctr, Covington, LA, US |
| 10:30 am 37 |
Dramatic CD4+ T Cell Depletion in the Intestine Is a Hallmark of SIV Infection in Natural Hosts
Ivona Pandrea*1, C Apetrei1, J Dufour1, N Dillon1, J Barbercheck1, N Katz1, P Marx1, V Hirsch2, A Lackner1, and R Veazey1
1Tulane Natl Primate Res Ctr, Covington, LA, US and 2NIAID, NIH, DHHS, Bethesda, MD, US |
| 10:45 am 38 |
High Frequencies of Infected CD4+ T Cells in the Gastrointestinal Tract Is Associated with Poor Mucosal Immune Reconstitution after HAART
Jason Brenchley*1, T Schacker2, D Price1, M Larson2, A Khoruts2, G Beilman2, A Haase2, and D Douek1
1Vaccine Res Ctr, NIAID, NIH, DHHS, Bethesda, MD, US and 2Univ Minnesota, Minneapolis, US |
| 11:00 am 39 |
Initiation of HAART during Primary HIV-1 Infection Results in Better Restoration and Maintenance of Mucosal CD4+ T Cells
M Guadalupe1, E Reay1, S Sankaran1, M George1, B Shacklett1, J Flamm2, J Wegelin1, T Prindiville1, Satya Dandekar*1, and S Dandekar
1Univ of California, Davis, US and 2Kaiser Permanente Med Group, Sacramento, CA, US |
| 11:15 am 40 |
Restoration of Memory CD4+ CCR5+ T Cells in the Gastrointestinal Tract during the Chronic Stage of SIV Infection Predicts Long-term Non-progression
Binhua Ling*, R Veazey, M Hart, M Kuroda, B Pahar, and P Marx
Tulane Natl Primate Res Ctr, Tulane Univ, Covington, LA, US |
| 11:30 am 41 |
CD4+ T-cell Quantification within Gut Lamina Propria of HIV Patients after HAART
Jason Baker*1, M Larson1, A Khoruts1, A Haase1, and T Schacker1
1Univ of Minnesota, Minneapolis, US |
| 11:45 am 42 |
AIDS-defining CD4 T-cell Levels Correlate with Expanded Co-receptor Usage during Nonpathogenic SIVsm Infection of Sooty Mangabeys
Jeffrey Milush*1, J Reeves2, D Zhou1, A Muthukumar1, E Chacko1, S Gordon3, K Stefano-Cole4, S Staprans3, G Silvestri3, and D Sodora1
1Univ of Texas Southwestern Med Ctr, Dallas, US; 2Univ of Pennsylvania, Philadelphia, US; 3Emory Univ, Atlanta, GA, US; and 4Univ of Pittsburgh, PA, US |
| 12:00 pm 43 |
CXCR4-tropic Viruses Are Common among Antiretroviral Treated Patients with Detectable Viremia and Associated with Lower Treatment-mediated CD4 Gains
Peter Hunt*1, J Martin1, M Bates2, W Huang2, S Spudich1, R Price1, D Williamson3, E Sinclair3, R Hoh1, and S Deeks1
1Univ of California, San Francisco, US; 2Monogram Biosci, South San Francisco, CA, US; and 3Gladstone Inst of Virology and Immunology, Univ of California, San Francisco, US |
| 12:15 pm 44LB |
The Effect of HIV Subtype on Rapid Disease Progression in Rakai, Uganda
Oliver Laeyendecker*1, X Li2, M Arroyo3, F McCutchan3, R Gray2, M Wawer4, D Serwadda5, F Nalugoda6, G Kigozi6, T Quinn1, and Rakai Hlth Sci Prgm
1NIAID, NIH and Johns Hopkins Med Inst, Baltimore, MD, US; 2Johns Hopkins Univ, Bloomberg Sch of Publ Hlth, Baltimore, MD, US; 3US Military HIV Res Prgm, Rockville, MD, US; 4Columbia Univ, Mailman Sch of Publ Hlth, New York, NY, US; 5Inst of Publ Hlth, Makerere Univ, Kampala, Uganda; and 6Uganda Virus Res Inst, Entebbe |
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