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Session 22
Oral Abstracts
Immunological Correlates of Protection: What Works and What Doesn't
Tuesday, 10 am - 12:30 pm
Room: Ballroom 5-6 |
Moderators: |
Barton Haynes
Duke Univ Sch of Med, Durham, NC, US
Richard Koup
Vaccine Res Ctr, NIAID, NIH, Bethesda, US
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| 10:00 am 91 |
Lack of Neutralizing Antibody Response to HIV-1 Predisposes to Superinfection
Davey Smith*1, M Strain2, S Frost1, S Pillai3, J Wong3, T Wrin4, C Petropoulos4, E Daar5,6, S Little1, and D Richman1,7
1Univ of California, San Diego, La Jolla, US; 2Symmunity, La Jolla, CA, US; 3VAMC, San Francisco, CA, US; 4Monogram Biosci, South San Francisco, CA, US; 5Los Angeles BioMed Res Inst, Harbor-Univ of California Med Ctr, Torrance, US; 6David Geffen Sch of Med, Univ of California, Los Angeles, US; and 7VA San Diego Hlthcare System, CA, US |
| 10:15 am 92 |
Broad Neutralization of HIV-1 Variants in Couples without Evidence of Systemic Superinfection Despite Exposure
J McConnell1, Y Liu2, C Kreis1, J Marcus1, L Bragg1, C Chappey2, E Stawiski2, T Wrin2, F Hecht3, and Robert Grant*1
1Gladstone Inst, San Francisco, CA, US; 2Monogram Biosci, South San Francisco, CA, US; and 3Univ of California, San Francisco, US |
| 10:30 am 93 |
Non-neutralizing Antibody that Prevents SIV Infection in Neonatal Rhesus Macaques Potently Inhibits SIV in the Presence of Rhesus Macaque Effector Cells
Donald Forthal*1, G Landucci1, K Stefano Cole2, J Becerra1, M Marthas3, and K Van Rompay3
1Univ of California Sch of Med, Irvine, US; 2Univ of Pittsburgh Sch of Med, PA, US; and 3California Natl Primate Res Ctr, Univ of California, Davis, US |
| 10:45 am 94 |
Simian Immunodeficiency Virus Engrafted with HIV-1-specific Epitopes: Replication, Neutralization, and Survey of HIV-1+ Plasma
E Yuste1, H Sanford1, J Bixby1, S Little2, M Zwick3, T Greenough4, D Burton3, D Richman2,5, R Desrosiers1, and Welkin Johnson*1
1New England Primate Res Ctr, Harvard Med Sch, Southborough, MA, US; 2Univ of California, San Diego, US; 3Scripps Res Inst, La Jolla, CA, US; 4Univ of Massachusetts Med Sch, Worcester, US; and 5VA San Diego Hlthcare System, La Jolla, CA, US |
| 11:00 am 95 |
Defining and Measuring HIV-1 Escape from CTL: Epitope-dependent Avidity Thresholds
M Bennet, H Ng, A Ali, and Otto O. Yang*
David Geffen Sch of Med, Univ of California, Los Angeles Med Ctr, US |
| 11:15 am 96 |
Localized Populations of CD8- SIV-specific T Cells in Lymphoid Follicles and Vaginal Epithelium
Pamela Skinner*1, T Mattila1, C White1, A Hage1, R Sunderman1, D Watkins2, C Miller3, E Connick4, and A Haase5
1Univ of Minnesota, St Paul, US; 2Univ of Wisconsin, Madison, US; 3Univ of California, Davis, US; 4Univ of Colorado Hlth Sci Ctr, Denver, US; and 5Univ of Minnesota, Minneapolis, US |
| 11:30 am 97 |
Maintenance of HIV-specific CD4+ T Cell Help Distinguishes HIV-2 from HIV-1 Infection
Melody Duvall*1,2, A Jaye3, T Dong1, J Brenchley2, D Jeffries3, D Douek2, A McMichael1, H Whittle3, R Koup2, and S Rowland-Jones1,3
1Weatherall Inst of Molecular Med, Oxford, UK; 2Vaccine Res Ctr, NIAID, NIH, DHHS, Bethesda, MD, US; and 3MRC Labs, Fajara, Gambia |
| 11:45 am 98 |
Immune Control of HIV Infection: Predictability in the Midst of Chaos
Bruce Walker
Partners AIDS Res Ctr, Harvard Med Sch, Boston, MA, US |
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