Session 52 - 13th CROI

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Session 52 Poster Abstracts
Viral Envelope: Tropism and Trans Infection
Wednesday, 1:30 - 3:30 pm
Poster Hall

220	Structural Analysis Indicates that HIV Envelope Binding to DC-SIGN Involves 2G12 Binding Site Won-Pyo Hong*, S Nguyen, S Su, and B Lee Geffen Sch of Med, Univ of California, Los Angeles, US
221	The V2 Loop Is a Major Determinant of SIV_sm Envelope Adaptation to Rhesus Macaques Thomas Vanderford*¹, L Demma², M Feinberg³, S Staprans¹, and J Logsdon⁴ ¹Emory Univ, Atlanta, GA, US; ²CDC, Atlanta, GA, US; ³Merck, Philadelphia, PA, US; and ⁴Univ of Iowa, Iowa City, US
222	Replication-competent Variants of HIV-1 Containing Deletions within the V3 Loop Mark Biscone*, K McGeehan, A Polachini De Oliveira, B Haggarty, J Romano, R Doms, and J Hoxie Univ of Pennsylvania, Philadelphia, US
223	Loss of N-linked Glycosylation in HIV-1 Subtype C Envelope Glycoprotein Is a Major Determinant of CCR5-to-CXCR4 Switch in Co-receptor Usage Thomas Ndolo*¹, E Johnston², A Aggrawal³, M Vajaypayee³, P Seth³, D Katzenstein², and S Dandekar¹ ¹Univ of California, Davis, US; ²Stanford Univ, CA, US; and ³All India Inst of Med, New Delhi
224	A 5 Amino Acid Insert within the V3 loop of HIV-1 Envelope Appears to be Derived from the Human Genome Elizabeth Johnston*, B McColgan, and D Katzenstein Stanford Univ, CA, US
225	Differential Behavior of Glycoproteins GP120 from Acute HIV-1 Infections in the DC-Sign Pathway Alexandra Vallon-Eberhard*, M M Fiers-Didelot, F Giroux, F Reynard, C Guillon, F Bedin, and B Verrier Lyon Biosci, CERVI, France
226	Donor and Recipient Env from Heterosexual Transmission Pairs Require High Receptor Levels for Entry Melissa Alexander*¹, E Platt², J Mulenga³, S Allen¹, D Kabat², C Derdeyn¹, and E Hunter¹ ¹Emory Univ, Atlanta, GA, US; ²Oregon Hlth Sci Univ, Portland, US; and ³Univ Teaching Hosp, Lusaka, Zambia
227	Relative Utilization and T20 Sensitivity of CCR5- and CXCR4-mediated Entry by R5X4 Isolates into Primary Macrophages Yanjie Yi*, L Loftin, and R Collman Univ of Pennsylvania, Philadelphia, US
228	Global Gene Expression Profiles Altered in Primary Macrophages by HIV-1 M-R5 but not T-X4 Envelope Joseph Brown*¹, J Kohler¹, J Sleasman², and M Goodenow¹ ¹Univ of Florida, Gainesville, US and ²Univ of South Florida, St Petersburg, US
229	Primary HIV-1-only-using Isolates Do not Accurately Represent the in vivo Replicating Quasi-species M Aasa-Chapman, K Aubin, C Seymore, I Williams, and Aine McKnight* Univ Coll, London, UK
230	Kinetic Analysis of Envelope-mediated Fusion of CXCR4- and CCR5-tropic HIV-1 Using a Temperature-arrested Intermediate Hamani Henderson*¹ and T Hope² ¹Univ of Illinois Coll of Med, Chicago, US and ²Northwestern Univ, Feinberg Sch of Med, Chicago, IL, US
231	Substitution of Membrane Active Peptides into the HIV-1 Tryptophan-rich Membrane Proximal External Region of gp41 Can Preserve Fusion but not Infectivity Sundaram Ajay Vishwanathan* and E Hunter Emory Univ, Atlanta, GA, US
232	HIV-1 Gag Regulates Envelope Association with Detergent Resistant Membranes J Bhattacharya, A Repik, and Paul Clapham* Univ of Massachusetts Med Sch, Worcester, US
233	HIV-1 Co-receptor Tropism in Triple-class-experienced Patients: Baseline Correlates and Relationship to Enfuvirtide Response Thomas Melby*¹, M Despirito¹, R Demasi¹, M Greenberg¹, G Heilek-Snyder², and N Graham¹ ¹Trimeris, Morrisville, NC, US and ²Roche, Palo Alto, CA, US
234	Mature Monocyte-derived Dendritic Cells Capture and Trans-infect HIV-1 Independently of DC-SIGN Nuria Izquierdo Useros*, J Blanco, M Fernández-Figueras, I Erkizia, P Parrales, L Ruiz, B Clotet, and J Martinez Picado Germans Trias i Pujol Hosp, Badalona, Spain
235	Effect of Polymorphisms in the DC-SIGNR Neck Domain on the Interaction with HIV-1 and other Pathogens Thomas Gramberg*^1,2, H Hofmann³, C Chaipan^1,2, A Marzi^1,2, H Liu⁴, T Andrus⁴, T Zhu⁴, S Pöhlmann^1,2, and A Wegele^1,2 ¹Inst for Virology, Erlangen, Germany; ²Nikolaus-Fiebiger-Ctr, Erlangen, Germany; ³Christian-Albrechts-Univ, Kiel, Germany; and ⁴Univ of Washington, Seattle, US
236	Role of L-selectin CD62L in Virus Attachment on Endothelial Cells and Trans-infection of CD4⁺ T Lymphocytes Sandra Thibault* and M Tremblay Laval Univ, Canada