Session 67 - 13th CROI

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Session 67 Poster Abstracts
Neuropathogenesis: Virology and Immunology
Monday, 1:30 - 3:30 pm
Poster Hall

329	HIV-1 Tropism for the Central Nervous System: Brain-derived Envelope Glycoproteins with Lower CD4 Dependence and Reduced Sensitivity to a Fusion Inhibitor Julio Martin-Garcia*¹ and F Gonzalez-Scarano² ¹Drexel Univ Coll of Med, Philadelphia, PA, US and ²Univ of Pennsylvania, Philadelphia, US
330	Identification of Residue 308 in the V3 loop of HIV gp120 as a Brain Signature Position Elaine Thomas*^1,2, R Dunfee^1,2, D Bogdan³, J Stanton³, K Kunstman³, S Wolinksy³, and D Gabuzda^1,2 ¹Dana-Farber Cancer Inst, Boston, MA, US; ²Harvard Sch of Publ Hlth, Boston, MA, US; and ³Northwestern Univ, Feinberg Sch of Med, Chicago, IL, US
331	CSF Pleocytosis Is Associated with Viral Trafficking from Blood into CNS Hai Shao*¹, D Smith¹, J Moreno¹, S Letendre², P Jordan¹, J Wong³, C Ignacio¹, D Richman⁴, S Frost², and R Ellis² ¹Univ of California, San Diego, US; ²HIV Neurobehavioral Res Ctr, Univ of California, San Diego, US; ³VA Hlthcare System, San Francisco, CA, US; and ⁴VA Hlthcare System, San Diego, CA, US
332	Role of CCR3 in CNS HIV-1 Infection Lokesh Agrawal* and D Strayer Thomas Jefferson Univ, Philadelphia, PA, US
333	Anti-HIV Cytotoxic T Lymphocytes (CTL) in Cerebrospinal Fluid and Peripheral Blood of Immune Controllers of Plasma Viremia S Kalams, K Brady, B Simmons, J Conrad, S Lorey, S Montgomery, J Nicotera, and David W Haas* Vanderbilt Univ Sch of Med, Nashville, TN, US
334	Defining Pathogenic Pathways for Murine HIV-1 Encephalitis in Immunodeficient Mice that Reflect Deficits in Adaptive Immunity and NK Cell Function Santhi Gorantla*, E Miller, H Klasek, H Dou, J Morehead, H Gendelman, and L Poluektova Univ of Nebraska Med Ctr, Omaha, US
335	Copaxone Regulation of Innate and Adaptive Imminty induces Suppression of Neuroinflammation and Elicits Neuronal Protection in Murine Models of HIV-1 Encephalitis Santhi Gorantla*¹, L Poluektova¹, H Klasek¹, L Walters¹, J Nelson¹, H Dou¹, T Ikezu¹, D Volsky², M Boska¹, and H Gendelman¹ ¹Univ of Nebraska Med Ctr, Omaha, US and ²Columbia Univ Mailman Sch of Publ Hlth, New York, NY, US
336	Activation of Peroxisome Proliferator-activated Receptor-g Suppresses HIV-1 Replication in Blood and Brain in an Animal Model for HIV-1 Encephalitis Raghava Potula*, B Knipe, J Liebhart, K Schall, H Dou, and Y Persidisky Univ of Nebraska Med Ctr, Omaha, US
337	HIV-1-infected or Immune-activated Macrophages Regulate SDF-1 Production by Human Astrocytes through IL-1b Hui Peng*, N Whitney, N Erdmann, A Ghorpade, and J Zheng Univ of Nebraska Med Ctr, Omaha, US
338	Anti-HIV-1 and Anti-Apoptotic Effects of D-Ala-Peptide T-Amide in Human Macrophages and in a Neuronal Cell Line Michela Pollicita*¹, M Ruff², M Polianova², C Pert², A Ranazzi¹, C Perno¹, and S Aquaro¹ ¹Univ of Tor Vergata, Rome, Italy and ²Georgetown Univ, Washington, DC, US
339	IFNg Augments HIV Productive Infection of Astrocytes Deborah Carroll-Anzinger* and L Al-Harthi Rush Univ Med Ctr, Chicago, IL, US
340	HIV-1 gag DNA Is Present in Neural Progenitors Harvested by Laser Capture Microdissection from Archival Pediatric Brain Lynnae Schwartz*¹, A Dunn-Pirio², S Ryschkewitsch³, L Durham¹, L Civitello^4,5, R Hazra⁵, D Lawrence¹, and E Major¹ ¹Natl Inst of Neurologic Disorders and Stroke, NIH, DHHS, Bethesda, MD, US; ²George Washington Univ, Washington, DC, US; ³Stone Ridge of the Sacred Heart, Bethesda, MD, US; ⁴Children's Natl Med Ctr, Washington, DC, US; and ⁵NCI, NIH, DHHS, Bethesda, MD, US
341	Long-term Administration of Ethanol Leads to Increased Blood-Brain Barrier Leakage during the Primary Phase of Infection of Macaques with Simian/Human Immunodeficiency Virus M. Sarah Hill*, E Mulcahy, N Culley, L Gomez, N Berman, and E Stephens Univ of Kansas Med Ctr, Kansas City, US
342	Human Polyomavirus JC Crosses in vitro Blood-Brain-Barrier by Infecting Human Brain Microvascular Endothelial Cells Moti Chapagain*, T Nguyen, S Verma, and V Nerurkar Univ of Hawaii, Honolulu, US