Background:  New cases of HIV among US adolescents and young adults continue to be reported with alarming frequency. To the extent that trends do not suggest significant slowing of the epidemic in populations most affected by the epidemic, efforts to prevent HIV infection among US adolescents and young adults, including HIV prophylactic HIV vaccines must continue.

Conclusions:  The goal of this presentation to is describe the state of the HIV epidemic among adolescents and young adults in the United States. Specifically, this presentation will:  describe trends in incidence of new HIV diagnoses among US adolescents and young adults; compare and contrast trends and risk factors between male and female adolescents; and discuss implications of these data for the inclusion of adolescents and young adults in domestic HIV vaccines and microbicide trials.