Session 10 - CROI 2007

Session 10 Oral Abstracts
Pathogenetic Factors Affecting HIV-Specific Immune Responses
Monday, 10 am - 12 noon
Room: Room 408

10:00 am 21	Superinfection Susceptibility and Low Neutralizing Serum Responses in Treated Persons with Suppressed Plasma Viral RNA Levels J McConnell¹, T Wrin², Y Liu², C Kreis¹, L Bragg¹, F Hecht³, N Parkin², Robert M Grant^1,3, and Robert M Grant^1,3 ¹Gladstone Inst of Virology and Immunology, Univ of California, San Francisco, US; ²Monogram Biosci, South San Francisco, CA, US; and ³Univ of California, San Francisco, US
10:15 am 22	Specific Amino Acids in the N-terminus of the gp41 Ectodomain Contribute to the Stabilization of a Soluble, Cleaved gp140 Envelope Glycoprotein from HIV-1 Antu Dey*, K David, P Klasse, and J Moore Weill Med Coll of Cornell Univ, New York, NY, US
10:30 am 23	Presence of HLA Class I-associated Cytotoxic T Lymphocyte Escape Mutations in Chronic Untreated HIV Infection Is Significantly Correlated with Clinical Markers of More Severe Disease Progression Zabrina Brumme^1,2, Zabrina Brumme^1,2, C Brumme^1,2, C Brumme^1,2, C Kadie³, J Carlson³, C Chui², T Mo², J Montaner², B Walker¹, D Heckerman³, and P Harrigan² ¹Partners AIDS Res Ctr, Massachusetts Gen Hosp, Boston, US; ²BC Ctr for Excellence in HIV/AIDS, Vancouver, Canada; and ³Microsoft Res, Redmond, WA, US
10:45 am 24	Relationship between HLA Genotype and the Functional Profile of Antigen-specific CD8 T Cells Alexandre Harari*¹, C Cellerai¹, J Kostler², S Gaudieri³, I James³, M John³, R Wagner², S Mallal³, and G Pantaleo¹ ¹Ctr Hosp Univ Vaudois Lausanne, Switzerland; ²Univ Regensburg, Germany; and ³Ctr for Clinical Immunology and Biomed Stats, Royal Perth Hosp, Murdoch Univ, Australia
11:00 am 25LB	A Polymorphism in the FcgRIIIa Gene is Associated with HIV Infection Risk Donald Forthal*, G Landucci, and T Phan Univ of California Sch of Med, Irvine, US
11:15 am 26	Protective HLA Class I Alleles Select HIV-1 Mutants and Slow Disease Progression John Frater*¹, H Brown¹, A Oxenius², H Gunthard³, C Brander⁴, P Kiepiela⁵, B Walker^4,5, B Walker^4,5, P Goulder^4,6, P Goulder^4,6, A McLean⁶, and R Phillips¹ ¹The James Martin 21st Century Sch, Oxford Univ, UK; ²Inst for Microbio, Eidgenössische Technische Hochschule, Zürich, Switzerland; ³Univ Hosp Zurich, Switzerland; ⁴Partners AIDS Res Ctr, Massachusetts Gen Hosp, Charlestown, US; ⁵HIV Pathogenesis Prgm, Doris Duke Med Res Inst, Univ of KwaZuluNatal, Durban, South Africa; and ⁶Oxford Univ, UK
11:30 am 27	Evidence of a Protective Role for Cytokine/Chemokine Production in HIV Infection Joseph Casazza*¹, J Brenchley¹, R Ayana¹, M Roederer¹, D Douek¹, M Betts², and R Koup¹ ¹Vaccine Res Ctr, NIAID, NIH, Bethesda, MD, US and ²Univ of Pennsylvannia, Philadelphia, US
11:45 am 28	Substantial CD4⁺ T-cell Recovery and Reconstitution of Tissue Architecture in Gut-associated Lymphoid Tissue in Advanced HIV-1 Infection following Initiation of HAART E Connick¹, Derek Shenefelt^1,2, Derek Shenefelt^1,2, J Folkvord¹, M Thrun³, S MaWhinney¹, J Gathe⁴, S Lundy⁵, and S Becker⁶ ¹Univ of Colorado Hlth Sci Ctr, Denver, US; ²Weber State Univ, Ogden, UT, US; ³Denver Dept of Publ Hlth, CO, US; ⁴Therapeutic Concepts, Houston, TX, US; ⁵Pharma Product Devt, Inc, Menlo Park, CA, US; and ⁶AnorMED Inc, Langley, Canada