Session 23 - CROI 2007

Session 23 Oral Abstracts
Pathogenesis of Acute and Chronic Infection
Tuesday, 10 am - 12:15 pm
Room: Room 403

10:00 am 64	Endogenous Retroviruses of Mammalian Genomes: Molecular Biology and Roles in Physiology and Physiopathology Thierry Heidmann Inst Gustave Roussy, Villejuif, France
10:30 am 65	Microbial Translocation Is a Cause of Systemic Immune Activation in Chronic HIV Infection Jason Brenchley*¹, D Price¹, T Schacker², G Silvestri³, O Lambotte⁴, A Landay⁵, L Picker⁶, M Lederman⁷, S Deeks⁸, and D Douek¹ ¹Vaccine Res Ctr, NIAID, NIH Bethesda, MD, US; ²Univ of Minnesota, Minneapolis, US; ³Univ of Pennsylvania, Philadelphia, US; ⁴Ctr Univ Hosp Bicetre, France; ⁵Rush Med Coll, Chicago, IL, US; ⁶Oregon Hlth and Sci Univ, Portland, US; ⁷Case Western Reserve Univ, Cleveland, OH, US; and ⁸Univ of California, San Francisco, US
10:45 am 66	PD-1^hi SIV-specific CD8⁺ T Cells Express Multiple Effector Function and Have Low Proliferative Capacity and High Sensitivity to Activation-induced Cell Death Consatntinos Petrovas*¹, D Price¹, J Mattapallil¹, C Geldmacher¹, V Cecchinato², D Ambrozak¹, M Roederer¹, D Douek¹, G Franchini², and R Koup¹ ¹Vaccine Res Ctr, NIAID, NIH, Bethesda, MD, US and ²NCI, NIH, Bethesda, MD, US
11:00 am 67	CD4 Reconstitution of Lymphoid Tissues Is Dependent on Earlier Initiation of HAART J Estes¹, J Brenchley², J Bathold¹, A Khoruts¹, G Beilman¹, J Baker¹, C Reilly¹, D Douek², A Haase¹, and Timothy Schacker*¹ ¹Univ of Minnesota, Minneapolis, US and ²Vaccine Res Ctr, NIAID, NIH, Bethesda, MD, US
11:15 am 68	HIV-1 Subtype D Infection Is Associated with Faster Disease Progression than Subtype A, in Spite of Similar HIV-1 Plasma Viral Loads Jared Baeten*¹, B Chohan¹, L Lavreys¹, V Chohan², R McClelland^1,2, R McClelland^1,2, L Certain¹, K Mandaliya³, W Jaoko², and J Overbaugh⁴ ¹Univ of Washington, Seattle, US; ²Univ of Nairobi, Kenya; ³Coast Provincial Gen Hosp, Mombasa, Kenya; and ⁴Fred Hutchinson Cancer Res Ctr, Seattle, WA, US
11:30 am 69	Mucosal CD4⁺ T-cell Depletion and Transient Immune Activation during the Early Phase of Non-pathogenic SIV Infection of Sooty Mangabeys Shari Gordon*¹, S Bosinger², J Brenchley³, C Apetrei⁴, I Pandrea⁴, D Kelvin⁵, S Staprans¹, D Douek³, D Sodora⁶, G Silvestri^1,7, and G Silvestri^1,7 ¹Emory Vaccine Ctr and Yerkes Natl Primate Res Ctr, Emory Univ, Atlanta, GA, US; ²Univ of Toronto, Canada; ³Vaccine Res Ctr, NIAID, NIH, Bethesda, MD, US; ⁴Tulane Natl Primate Res Ctr, Tulane Hlth Sci Ctr, Tulane Univ, Covington, LA, US; ⁵Univ Hlth Network, Toronto, Canada; ⁶Univ of Texas Southwestern, Dallas, US; and ⁷Univ of Pennsylvania Sch of Med, Philadephia, US
11:45 am 70	PD-1 Expression on HIV-specific CD4⁺ T Cells Is Driven by HIV Replication and Is Associated with T-cell Dysfunction M D'Souza, A Fontenot, D Mack, S Dillon, A Meditz, C Wilson, E Connick, and Brent Palmer* Univ of Colorado Hlth Sci Ctr, Denver, US
12:00 pm 71LB	Co-receptor Switch in a Macaque Infected with CCR5 (R5)-tropic Simian-Human Immunodeficiency Virus Siu-hong Ho*¹, L Shek¹, A Li¹, S Tasca¹, A Gettie¹, J Blanchard², D Boden¹, and C Cheng-Mayer¹ ¹Aaron Diamond AIDS Res Ctr, The Rockefeller Univ, New York, NY, US and ²Tulane Natl Primate Res Ctr, Tulane Univ, Covington, LA, US