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Session 33
Oral Abstracts
Late Breaking Phase III Trials of New Antiretrovirals
Tuesday, 6:30 - 7:10 pm
Room: West Hall B
Moderators:
John Coffin
Tufts Univ, Boston, MA, US and NCI-Frederick, MD, US
Christopher Aiken
Vanderbilt Univ Sch of Med, Nashville, TN, US
6:30 pm 104aLB
Efficacy and Safety of Maraviroc plus Optimized Background Therapy in Viremic, ART-experienced Patients Infected with CCR5-tropic HIV-1 in Europe, Australia, and North America: 24-Week Results
M Nelson
1
, G Fätkenheuer
2
, I Konourina
3
, A Lazzarin
4
, N Clumeck
5
, A Horban
6
, M Tawadrous
7
, J Sullivan
3
, H Mayer
7
, and Elna van der Ryst*
3
1
Chelsea and Westminster Hosp, London, UK;
2
Universitaetsklinik Köln, Germany;
3
Pfizer Global R&D, Sandwich, UK;
4
Hosp San Raffaele, Milan, Italy;
5
Ctr Hosp Univ St Pierre, Brussels, Belgium;
6
Szpital Zakazny Centrum Diagnostyki i Terapii AIDS, Warsaw, Poland; and
7
Pfizer Global R&D, New London, CT, US
104bLB
Efficacy and Safety of Maraviroc plus Optimized Background Therapy in Viremic ART-experienced Patients Infected with CCR5-tropic HIV-1: 24-Week Results of a Phase 2b/3 Study in the US and Canada
J Lalezari
1
, J Goodrich
2
, E DeJesus
3
, H Lampiris
4
, R Gulick
5
, M Saag
6
, C Ridgway
7
, M McHale
7
, E van der Ryst
7
, and Howard Mayer*
2
1
Quest Clin Res, Univ of California, San Francisco, US;
2
Pfizer Global R&D, New London, CT, US;
3
Orlando Immunology Ctr, FL, US;
4
San Francisco VAMC, Univ of California, US;
5
Weill Med Coll of Cornell Univ, New York, NY, US;
6
Univ of Alabama at Birmingham, US; and
7
Pfizer Global R&D, Sandwich, UK
6:50 pm 105aLB
Results of BENCHMRK-1, a Phase III Study Evaluating the Efficacy and Safety of MK-0518, a Novel HIV-1 Integrase Inhibitor, in Patients with Triple-class Resistant Virus
David Cooper*
1
, J Gatell
2
, J Rockstroh
3
, C Katlama
4
, P Yeni
5
, A Lazzarin
6
, J Chen
7
, R Isaacs
7
, H Teppler
7
, B Nguyen
7
, and for the BENCHMRK-1 Study Group
1
Univ of New South Wales, Sydney, Australia;
2
Univ of Barcelona, Spain;
3
Univ of Bonn, Germany;
4
Hosp Pitie Salpetriere, Paris, France;
5
Hosp Bichat Claude Bernard, Paris, France;
6
San Raffaele Sci Inst, Milan, Italy; and
7
Merck Res Labs, West Point, PA, US
105bLB
Results of BENCHMRK-2, a Phase III Study Evaluating the Efficacy and Safety of MK-0518, a Novel HIV-1 Integrase Inhibitor, in Patients with Triple-class Resistant Virus
Ron Steigbigel*
1
, P Kumar
2
, J Eron
3
, M Schechter
4
, M Markowitz
5
, M Loufty
6
, J Zhao
7
, R Isaacs
7
, B Nguyen
7
, H Teppler
7
, and for the BENCHMRK-2 Study Group
1
State Univ of New York at Stony Brook, US;
2
Georgetown Univ Med Ctr, Washington, DC, US;
3
Univ of North Carolina at Chapel Hill, US;
4
Federal Univ of Rio de Janeiro, Brazil;
5
Aaron Diamond AIDS Res Ctr, The Rockefeller Univ, New York, NY, US;
6
Canadian Immunodeficiency Res Collaborative, Toronto; and
7
Merck Res Labs, West Point, PA, US
7:10 pm 106
Update on the CONRAD Cellulose Sulfate Trial
G Doncel and L van Damme
CONRAD, Arlington, VA, US