Session 72 - CROI 2007

Session 72 Poster Abstracts
Neuropathogenesis: Virology and Immunology
Wednesday, 1 - 4 pm
Poster Hall

350	Envelope Determinants that Confer Highly Efficient Macrophage Infection and Neutralization Sensitivity in a Brain-derived HIV-1 Envelope Maria J. Duenas-Decamp*, P Peters, and P Clapham Univ of Massachusetts Med Sch, Worcester, US
351	Evidence for Distinct G-A Hypermutation Patterns in Blood and CSF-derived HIV-1: Correlation with Dementia, but Not with APOBEC-3G Levels in vivo Nitin Saksena*¹, B Wang¹, and J Carr² ¹Westmead Millennium Inst, Sydney, Australia and ²Inst of Molecular and Structural Virology, France
352	Excitotoxic Glutamate Production in HIV-1-infected Human Macrophage by Glutaminase C Nathan Erdmann*¹, C Tian¹, J Zhao¹, S Herek¹, N Curthoys², T Tsukamoto³, D Ferraris³, and J Zheng¹ ¹Univ Nebraska Med Ctr, Omaha, US; ²Colorado State Univ, Fort Collins, US; and ³MGI Pharma Inc, Baltimore MD, US
353	HIV-1-infected or Immune Activated Macrophages Affect Human Neural Progenitor Cell Function Hui Peng*, N Whitney, and J Zheng Univ of Nebraska Med Ctr, Omaha, US
354	Comparison of Different Viral Strains from Clade B and C on Macrophage-mediated Inflammatory Factor and Glutamate Production and Neurotoxicity Jialin Zheng*¹, A Lopez¹, Y Huang¹, A Persidsky¹, J He², H Zhang², J Zhao¹, and C Wood² ¹Univ of Nebraska Med Ctr, Omaha, US and ²Nebraska Ctr for Virology, Univ of Nebraska, Lincoln, US
355	HIV-1 gp120-stimulated Chemotaxis of Primary Human Macrophages Involves Chemokine Receptor-activated Protein Kinase Signaling Pathways Rick Cheung*, V Ravyn, A Ptasznik, and R Collman Univ of Pennsylvania, Philadelphia, US
356	Activation of the Kynurenine Pathway at the Blood-Brain Barrier: A Mechanism for Persistence of HIV in the Brain? R owe-young¹, M mukhtar², R pomerantz², G smythe³, D walker⁴, and bruce brew*¹ ¹St Vincent's Hosp, Sydney, Australia; ²Thomas Jefferson Univ, Philadelphia, PA, US; ³Univ of New South Wales, Sydney, Australia; and ⁴Monash Univ, Parkville, Australia
357	Altered Expression of Efflux Transporters on Blood-Brain Barrier During HIV-1 Encephalitis B Morsey¹, K Schall¹, D Heilman¹, and Yuri Persidsky*¹ ¹Univ of Nebraska Med Ctr, Omaha, US
358	Restriction of HIV Replication in Astrocytes and the Ability of IFNg to Modulate this Restriction Is Regulated by a Downstream Effector of the Wnt Signaling Pathway D Carroll-Anzinger¹, V Adarichev¹, F Kashanchi², Alan Landay*¹, and L Al-Harthi¹ ¹Rush Univ Med Ctr, Chicago, IL, US and ²George Washington Univ, Washington, DC, US
359	Interferon-a and -ß Restrict Polyomavirus JC Replication in Primary Human Fetal Glial Cells: Implications for Progressive Multifocal Leukoencephalopathy Therapy S Verma, J G Co, L Sumibcay, U Gurjav, and Vivek R Nerurkar* Univ of Hawaii, Honolulu, US
360	HIV-1 Vpr Potently Induces Programmed Cell Death in the CNS in vivo X Cheng¹, M Mukhtar², E Acheampong¹, A Srinivasan¹, M Rafi¹, R Pomerantz³, and Zahida Parveen*¹ ¹Thomas Jefferson Univ, Philadelphia, PA, US; ²Drexel Univ Coll of Med, Philadelphia, PA, US; and ³Tibotec Inc, Yardley, PA, US
361	Role of the Transcriptional Factor E2F1 in CXCR4-mediated Neurotoxicity and HIV Neuropathology Saori Shimizu*, M Khan, and O Meucci Drexel Univ Coll of Med, Philadelphia, PA, US
362	GB Virus C Replication in Cerebrospinal Fluid of HIV⁺ Individuals Stefania Dispinseri*, S Bagaglio, C Lodrini, P Cinque, A Bestetti, A Lazzarin, and G Morsica San Raffaele Sci Inst, Milan, Italy