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Session 76
Poster Abstracts
Neurocognitive Dysfunction: Immunologic Mechanisms, Biomarkers, and CNS Drug Penetration
Monday, 1 - 4 pm
Poster Hall |
381
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Single-agent Therapy with Lopinavir/ritonavir Controls HIV-1 Viral Replication in the Central Nervous System
Rosa F Yeh*1,2, Rosa F Yeh*1,2, S Letendre3, I Novak2,4, I Novak2,4, B Lipman5, A Hermes5, C Mayberry6, B Miguel1, J Nemecek6, M Norton5, and J Gathe, Jr1
1Therapeutic Concepts, Houston, TX, US; 2Univ of Texas, Houston, US; 3Univ of California, San Diego, US; 4Park Plaza Hosp, Houston, TX, US; 5Abbott Labs, Abbott Park, IL, US; and 6Donald R Watkins Fndn, Houston, TX, US |
| 382a |
Could Cerebrospinal Fluid ART Penetration Scores Predict Viral Rebound in ART-naďve Individuals Who Achieve Plasma Viral Load Suppression on Their First Therapy?
Andrea Antinori*1, A Cozzi-Lepri2, P Cinque3, M Giancola1, A De Luca4, C Mussini5, C Torti6, L Sighinolfi7, V Colangeli8, A d'Arminio Monforte9, and ICoNA Cohort
1Natl Inst of Infectious Diseases, L Spallanzani, Rome, Italy; 2Royal Free and Univ Coll London Med Sch, UK; 3Inst San Raffaele, Milan, Italy; 4Univ Cattolica Sacro Cuore, Rome, Italy; 5Policlin of Modena, Italy; 6Univ degli Studi, Brescia, Italy; 7Hosp St Anna, Ferrara, Italy; 8Univ of Bologna, Italy; and 9Azienda Hosp, Polo Univ San Paolo, Milan, Italy |
| 382b |
Suppression of HIV Replication in Plasma Requires Suppression of HIV Replication in Cerebrospinal Fluid
Christina Marra*1, S Sinha2, D Clifford3, S Evans2, S Letendre4, R Ellis4, F Aweeka5, G Schifitto6, R Coombs1, K Robertson7, and Adult AIDS Clinical Trials Group 736 Team
1Univ of Washington, Seattle, US; 2Harvard Sch of Publ Hlth, Boston, MA, US; 3Washington Univ of St Louis, MO; 4Univ of California, San Diego, US; 5Univ of California, San Francisco, US; 6Univ of Rochester, NY, US; and 7Univ of North Carolina at Chapel Hill, US |
383
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Recommended Earlier Initiation of ART Based on Nadir CD4 Cell Count as a Risk Factor for HIV-related Neurocognitive Impairment
Jose A. Muńoz-Moreno*1, C Rodríguez1, A Prats1, M Ferrer1, E Negredo1, M Garolera2, and B Clotet1
1Lluita contra la SIDA Fndn, Germans Trias i Pujol Hosp, Barcelona, Spain and 2Terrassa Hosp, Barcelona, Spain |
384
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Clinical Evidence of Antiviral Activity of Serotonin Reuptake Inhibitors and HMG-CoA Reductase Inhibitors in the Central Nervous System
Scott Letendre*1, J Marquie-Beck1, D Clifford2, A Collier3, B Gelman4, J McArthur5, J McCutchan1, D Simpson6, I Grant1, R Ellis1, and CHARTER Group
1Univ of California, San Diego, US; 2Washington Univ, St Louis, MO, US; 3Univ of Washington, Seattle, US; 4Univ of Texas Med Branch, Galveston, US; 5Johns Hopkins Univ, Baltimore, MD, US; and 6Mt Sinai Sch of Med, New York, NY, US |
385
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Distinct Neuropsychological Deficit Pattern in HIV-1+ Patients with Higher CSF than Plasma Viral Load
Gabriele Arendt*1, T Nolting1, I W Husstedt2, N Gregor2, E Koutsilieri3, M Maschke4, M Obermann4, S Sopper5, P Riederer3, V ter Meulen3, and Competence Network HIV/AIDS
1Univ Hosp of Duesseldorf, Germany; 2Univ Hosp of Muenster, Germany; 3Univ of Wuerzburg, Germany; 4Univ Hosp of Duisburg-Essen, Germany; and 5German Primate Ctr, Goettingen |
386
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Central Nervous Cytokine Patterns in Different Stages of HIV Infection
Thorsten Nolting*1, E Koutsilieri2, I W Husstedt3, N Gregor3, M Maschke4, M Obermann4, P Riederer2, S Sopper5, V ter Meulen2, G Arendt1, and Competence Network HIV/AIDS
1Univ Hosp of Duesseldorf, Germany; 2Univ of Wuerzburg, Germany; 3Univ Hosp of Muenster, Germany; 4Univ Hosp of Duisburg-Essen, Germany; and 5German Primate Ctr, Goettingen |
| 387 |
Patterns of Cytokine Change in Cerebrospinal Fluid and Blood in Progressive HIV Infection and AIDS Dementia Complex: Survey Using Multiplex Bead Technology Simultaneously Measuring 29 Analytes
P Cinque1, M Gisslen2, L Hagberg2, E Lee3, N Lollo3, S Spudich3, and Richard Price*3
1San Raffaele Hosp, Milan, Italy; 2Sahlgrenska Academy at Göteborg Univ, Sweden; and 3Univ of California, San Francisco, US |
| 388 |
A Proteomic Fingerprint of Cerebrospinal Fluids from Individuals with HIV-1-associated Dementia
W Rozek1, S Holloway1, M Ricardo-Dukelow1, L Melendez2, and Pawel Ciborowski*1
1Univ of Nebraska Med Ctr, Omaha, US and 2Specialized NeuroAIDS Prgm, San Juan, PR, US |
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