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Session 105
Poster Abstracts
Novel RTI Resistance Mutations and their Interactions
Tuesday, 1 - 4 pm
Poster Hall |
| 591 |
The A62V and S68G Mutations in HIV-1 Reverse Transcriptase Partially Restore the Replication Defect Associated with the K65R Mutation
Evguenia Svarovskaia*1, J Feng1, N Margot2, F Myrick1, D Goodman1, J Ly2, K White2, K Borroto-Esoda1, and M Miller2
1Gilead Sci, Durham, NC, US and 2Gilead Sci, Foster City, CA, US |
592
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Molecular Basis of Antagonism between K70E and K65R Tenofovir-associated Mutations in HIV-1 Reverse Transcriptase
Ron Kagan*1, T Lee2, S Potts1, and L Ross3
1Quest Diagnostics Nichols Inst, San Juan Capistrano, CA, US; 2Univ of Minnesota, Minneapolis, US; and 3GlaxoSmithKline, Research Triangle Park, NC, US |
593
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A Novel Mutation, N348I in HIV-1 Reverse Transcriptase Induced by NRTI Treatment, Confers Nevirapine Resistance
Atsuko Hachiya*1,2, Atsuko Hachiya*1,2, E Kodama3, S Sarafianos4, M Schuckman4, M Matsuoka3, M Takiguchi2, H Gatanaga1, and S Oka1
1AIDS Clin Ctr, Intl Med Ctr of Japan, Tokyo; 2Ctr for AIDS Res, Kumamoto Univ, Japan; 3Inst for Virus Res, Kyoto Univ, Japan; and 4Univ of Missouri Sch of Med, Columbia, US |
594
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A Mutation in the Connection Subdomain of the HIV-1 Reverse Transcriptase (N348I) Is Selected Commonly in vivo and Confers Decreased Susceptibility to Zidovudine and Nevirapine
S H Yap1,2, S H Yap1,2, B Wynhoven3, M Kuiper4, C W Sheen5, N Sluis-Cremer5, R Harrigan3, Gilda Tachedjian*1,2, and Gilda Tachedjian*1,2
1Burnet Inst, Melbourne, Australia; 2Monash Univ, Clayton, Australia; 3BC Ctr for Excellence in HIV/AIDS, Vancouver, Canada; 4Victorian Partnership for Advanced Computing, Melbourne, Australia; and 5Univ of Pittsburgh Sch of Med, PA, US |
| 595 |
Factors that Decrease HIV-1 RNase H Activity Increase Reverse Transcriptase Resistance to AZT-5’-triphosphate
Johan Lennerstrand*, M Bennett, E Orenstein, G Bluemling, M Ruckstuhl, and R Schinazi
Emory Univ Sch of Med/VAMC, Decatur, GA, US |
596
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Identification of a Mutation (A400T) in the Connection Domain of the HIV-1 Reverse Transcriptase Associated to Exposure and Resistance to NRTI
Bénédicte Roquebert*1,2, Bénédicte Roquebert*1,2, P Flandre1,3, P Flandre1,3, I Malet1,2, I Malet1,2, M Wirden1,2, M Wirden1,2, Z ait-arkoub1, V Boutonnet1, A Simon1,2, A Simon1,2, C Katlama1,2, C Katlama1,2, V Calvez1,2, V Calvez1,2, A G Marcelin1,2, and A G Marcelin1,2
1Hosp Pitie-Salpetriere, Paris, France; 2Univ Pierre and Marie Curie, Paris, France; and 3INSERM U720, Hosp Pitie-Salpetriere, Paris, France |
597
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L234F, a Unique HIV-1 RT Mutation Selected by NcRTI
D Jochmans1, M Van Ginderen1, M Ehteshami2, B Van Schoubroeck1, P Dehertogh1, Sabine Hallenberger*1, M Götte2, and K Hertogs1
1Tibotec BVBA, Mechelen, Belgium and 2McGill Univ, Montreal, Canada |
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