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Session 107
Poster Abstracts
Novel Mechanisms of Resistance to Pis
Monday, 1 - 4 pm
Poster Hall |
601
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TTNTRNS: An Amino Acid Insert near the p17/p24 Gag Cleavage Site Associated with Resistance to PI
Manabu Aoki*1,2, Manabu Aoki*1,2, H Aoki1, T Miyakawa1, H Mitsuya1,3, and H Mitsuya1,3
1Kumamoto Univ Sch of Med, Japan; 2Kumamoto Hlth Sci Univ, Japan; and 3NCI, NIH, Bethesda, MD, US |
| 602 |
An Investigation into the Influence of the Tipranavir-asssociated V82L/T Mutations on the Susceptibility to Darunavir and Brecanavir
R Elston1, Daniel Kuritzkes*2, and R Bethell1
1Boehringer Ingelheim Ltd, Laval, Canada and 2Brigham and Women's Hosp, Boston, MA, US |
603
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Analysis of Co-evolution between Mutations in PI Resistance and in Gag
J Shibata1, M Matsuda2, M Nishizawa2, F Ren1, H Tanaka1, and Wataru Sugiura*2
1Tokyo Med and Dental Univ, Japan and 2Natl Inst of Infectious Diseases, Tokyo, Japan |
| 604 |
Dominant Effect of HIV-1 gag Polymorphisms and Target Cell Type on Replicative Fitness, Protease Processing, and Drug Resistance
Maureen Goodenow*1, S Ho1, C Gavegnano1, R Coman1, M Morrow2, B Dunn1, C Fletcher3, and J Sleasman2
1Univ of Florida, Gainesville, US; 2Univ of South Florida, St Petersburg, US; and 3Univ of Colorado, Denver, US |
605
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Binding Kinetics of PI to Wild Type and Multi-drug Resistant HIV-1 Proteases: A Mechanistic Study of the Genetic Barrier to Resistance of Darunavir
M De Wit, I Keuleers, E Gustin, Inge Dierynck*, S Hallenberger, and K Hertogs
Tibotec BVBA, Mechelen, Belgium |
606
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Selection in vitro of HIV-1 Variants Highly Resistant to Darunavir Using a Mixture of HIV-1 Isolates Resistant to Multiple PI
Yasuhiro Koh*1, T Towata1, A Ghosh2, H Mitsuya1,3, and H Mitsuya1,3
1Kumamoto Univ Sch of Med, Japan; 2Purdue Univ, West Lafayette, IN, US; and 3NCI, NIH, Bethesda, MD, US |
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