Session 131 - CROI 2007

Session 131 Poster Abstracts
Pharmacokinetics of Antiretrovirals in Pregnancy and Delivery
Wednesday, 1 - 4 pm
Poster Hall

737	Lack of Placental Transfer of Enfuvirtide in an ex vivo Human Placental Cotyledon Perfusion Model Claudia Ferreira^1,2, Claudia Ferreira^1,2, P Ceccaldi^1,3, P Ceccaldi^1,3, B Visseaux⁴, L Gavard^1,3, L Gavard^1,3, G Peytavin⁴, S Gil⁵, L Mandelbrot^1,3, and L Mandelbrot^1,3 ¹Hosp Louis Mourier, Colombes, France; ²French Natl Agency for Res on AIDS and Viral Hepatitis; ³Univ Paris 7, France; ⁴Hosp Bichat-Claude Bernard, Paris, France; and ⁵UPRES EA 2706, Univ of Pharma Sci, Chatenay-Malabry, France
738a	Transplacental Passage of Tenofovir and other Antiretrovirals at Delivery Stefano Bonora*¹, D Gonzalez de Requena¹, E Chiesa², A Maccabruni³, M Forleo⁴, F Vichi⁵, S Fiore⁶, T Bini⁶, E Ferrazzi⁶, A d'Arminio Monforte⁶, and TARGET Study Group ¹Univ of Turin, Italy; ²Hosp di Circolo, Busto Arsizio, Italy; ³Univ of Pavia, Italy; ⁴Univ of Brescia, Italy; ⁵SM Annunziata Hosp, Florence, Italy; and ⁶Univ of Milan, Italy
738b	Tenofovir Pharmacokinetics during Pregnancy, at Delivery and Postpartum Sandra Burchett*¹, B Best², M Mirochnick³, C Hu⁴, E Capparelli², D Holland², E Smith⁵, B Sheeran⁶, J Read⁷, A Stek⁸, and PACTG P1026s Team ¹Children's Hosp Boston, MA, US; ²Univ of California, Los Angeles, Sch of Med, US; ³Boston Univ, MA, US; ⁴Harvard Sch of Publ Hlth, Boston, MA, US; ⁵NIAID, NIH, Bethesda, MD, US; ⁶Social & Sci Systems, Silver Spring, MD, US; ⁷Natl Inst of Child Hlth and Human Devt, NIH, Bethesda, MD, US; and ⁸Univ of Southern California, Los Angeles, US
739	ACTG 5153s: Pharmacokinetic Exposure and Virological Response in HIV-1-infected Pregnant Women Treated with PI Francesca Aweeka*¹, C Tierney², A Stek³, X Sun², S Cohn⁴, R Coombs⁵, P Lizak¹, A Kmack⁶, K Klingman⁷, and B Sha⁸ ¹Univ of California, San Francisco, US; ²Statistical & Data Analysis Ctr, Harvard Sch of Publ Hlth, Boston, MA, US; ³Univ of Southern California, Los Angeles, US; ⁴Univ of Rochester, NY, US; ⁵Univ of Washington, Seattle, US; ⁶Frontier Sci & Tech Res Fndn, Amherst, NY, US; ⁷Div of AIDS, NIAID, NIH, Bethesda, MD, US; and ⁸Rush Univ Med Ctr, Chicago, IL, US
740	Nelfinavir Pharmacokinetics (625-mg Tablets) during the Third Trimester of Pregnancy and Post-partum Jennifer Read*¹, B Best², A Stek³, C Hu⁴, E Capparelli², D Holland², S Burchett⁵, E Smith⁶, B Sheeran⁷, and M Mirochnick⁸ ¹Natl Inst of Child Hlth and Human Devt, NIH, Bethesda, MD, US; ²Univ of California, San Diego, US; ³Univ of Southern California, Los Angeles, US; ⁴Harvard Sch of Publ Hlth, Boston, MA, US; ⁵Children's Hosp Boston, MA, US; ⁶NIAID, NIH, Bethesda, MD, US; ⁷Social & Sci Systems, Silver Spring, MD, US; and ⁸Boston Univ, MA, US
741	The Pharmacokinetics of Saquinavir in New Tablet Formulation + Ritonavir (1000/100 mg Twice Daily) in HIV-1-infected Pregnant Women David Burger^1,2, David Burger^1,2, A Eggink¹, I Van der Ende³, D Hawkins⁴, M Vogel⁵, G Fatkenheuer⁶, J Molto⁷, C Richter⁸, P Koopmans^1,2, P Koopmans^1,2, M Schutz⁹, and the SARA study group ¹Radboud Univ Med Ctr, Nijmegen, The Netherlands; ²Nijmegen Univ Ctr for Infectious Diseases, The Netherlands; ³Erasmus Med Ctr, Rotterdam, The Netherlands; ⁴Chelsea and Westminster Hosp, London, UK; ⁵Univ Hosp, Bonn, Germany; ⁶Univ Hosp Cologne, Germany; ⁷Hosp Germans Trial i Pujol, Barcelona, Spain; ⁸Rijnstate Hosp Arnhem, The Netherlands; and ⁹Roche Pharma, Basel, Switzerland
742	Atazanavir-based HAART in Pregnancy D Ripamonti¹, D Cattaneo², M Airoldi¹, L Frigerio¹, P Bertuletti¹, M Ruggeri¹, G Remuzzi², F Suter¹, and Franco Maggiolo*¹ ¹Hosp Riuniti, Bergamo, Italy and ²Mario Negri Inst for Pharmacological Res, Bergamo, Italy
743	Lopinavir Drug Monitoring in 36 Pregnant Women Marie-Aude Khuong-Josses*¹, A Boussaïri¹, C Palette², and D Méchali¹ ¹Hosp Delafontaine, Saint-Denis, France and ²Ctr Hosp de Versailles, Le Chesnay, France
744	Genital Tract Diffusion of Different HIV PI in HIV-1-infected Pregnant Women Gilles Peytavin*¹, R Tubiana², C Ferreira³, C Crenn-Hebert³, B Visseaux¹, A G Marcelin², M Dommergues², and L Mandelbrot³ ¹Hosp Bichat-Claude Bernard, Paris, France; ²Hosp Pitie-Salpetriere, Paris, France; and ³Hosp L Mourier, Colombes, France