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Session 22
Oral Abstracts
New Mechanisms of Resistance and Virologic Failure
Tuesday, 10-11:30 am
Room: Ballroom B/C |
| 10:00 am 79 |
Mechanism by which N348I in HIV-1 Reverse Transcriptase Confers Dual Zidovudine/Nevirapine Resistance
Soo-Huey Yap*1,2, J Radzio3,4, N Sluis-Cremer3, and G Tachedjian1,5
1Burnet Inst, Melbourne, Australia; 2Monash Univ, Churchill, Australia; 3Univ of Pittsburgh Sch of Med, PA, US; 4Univ of Pittsburgh Grad Sch of Publ Hlth, PA, US; and 5Monash Univ, Clayton, Australia |
| 10:15 am 80 |
Molecular Mechanisms for 3’-Azido-3’-Dideoxythymidine-resistance Conferred by Mutations in the Connection and RNase H Domains of HIV-1 Reverse Transcriptase
Jessica Brehm*, N Sluis-Cremer, and J Mellors
Univ of Pittsburgh, PA, US |
| 10:30 am 81 |
Connection Domain Mutations N348I and A360V in HIV-1 RT Selectively Facilitate Excision of AZT by Improving Access to Transiently Formed RNA/DNA Hybrids
G Beilhartz, Maryam Ehteshami*, B Scarth, E Tchesnokov, and M Gotte
McGill Univ, Montreal, Canada |
| 10:45 am 82 |
Circumventing Drug Resistance: Using the Substrate Envelope Hypothesis to Develop Robust Novel HIV-1 Protease Inhibitors
M Nalam1, A Ali1, K Reddy1, M Altman2, S Chellappan3, S Anjum1, T Rana1, M Gilson3, B Tidor2, and Celia Schiffer*1
1Univ of Massachusetts Med Sch, Worcester, US; 2Massachusetts Inst of Tech, Cambridge, US; and 3Ctr for Advanced Res in Biotech, Univ of Maryland, Baltimore, US |
| 11:00 am 83 |
Presence of Minor Populations of Y181C Mutants Detected by Allele-specific PCRand Risk of Efavirenz Failure in Treatment-naïve Patients: Results of an ACTG 5095 Case-cohort Study
Roger Paredes*1,2, C Lalama3, H Ribaudo3, B Schackman4, C Shikuma5, W Meyer, III6, F Giguel1, K Squires7, R Gulick4, and D Kuritzkes1
1Brigham and Women`s Hosp, Harvard Med Sch, Boston, MA, US; 2Fndns irsiCaixa and Lluita contra la SIDA, Badalona, Spain; 3Harvard Sch of Publ Hlth, Boston, MA, US; 4Weill Med Coll of Cornell Univ, New York, NY, US; 5Univ of Hawaii, Honolulu, US; 6Quest Diagnostics, Baltimore, MD, US; and 7Jefferson Med Coll, Philadelphia, PA, US |
| 11:15 am 84LB |
Emergence of HIV-1 Drug Resistance among Breastfeeding Infants Born to HIV-infected Mothers Taking Antiretrovirals for Prevention of Mother-to-Child Transmission of HIV: The Kisumu Breastfeeding Study, Kenya
Clement Zeh*1, P Weidle2, L Nafisa1, H Musuluma1, J Okonji1, E Anyango1, P Bondo1, R Masaba1, M Thigpen2, and T Thomas1
1CDC Kenya, Kisumu and 2CDC, Atlanta, GA, US |
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