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Session 63
Poster Abstracts
Studies on Elite Controllers and Exposed Uninfected
Wednesday, 1-4 pm
Room: Hall D |
347
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Longitudinal Measurements of Ultra-sensitive Plasma HIV RNA and Quantitative Antibody Levels in HIV-1-infected Individuals Who Naturally Maintain Viral Loads below the Limit of Conventional Detection
Hiroyu Hatano*1, E Delwart1,2, P Norris1,2, R Hoh1, M Busch1,2, J Martin1, and S Deeks1
1Univ of California, San Francisco, US and 2Blood Systems Res Inst, San Francisco, CA, US |
348
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Low-level Virema in HIV-1-infected Patients Classified as Elite Controllers Compared to Patients on Suppressive ART
Sarah Palmer*1, A Wiegand1, T Miura2, B Block2, F Pereyra2, F Maldarelli1, J Mellors3, B Walker2, and J Coffin4
1HIV Drug Resistance Prgm, NCI, Frederick, MD, US; 2Partners AIDS Res Ctr, Massachusetts Gen Hosp, Boston, US; 3Univ of Pittsburgh, PA, US; and 4Tufts Univ, Boston, MA, US |
| 349 |
Ongoing Low-level Viral Replication and Polyfunctional CD8 T Cell Responses Detected in the HIV Elite Controllers
Florencia Pereyra*1, T Miura1, S Palmer2, B Block1, A Rothchild1, B Baker1, J Coffin2, and B Walker1
1Partners AIDS Res Ctr, Massachusetts Gen Hosp, Charlestown and Harvard Med Sch, Boston, US and 2NCI-Frederick, MD, US |
350
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Viral Dynamics of Elite Suppressors in HIV-1 Infection
Jason Dinoso*1, S Kim1, J Blankson1, and R Siliciano1,2
1Johns Hopkins Univ Sch of Med, Baltimore, MD, US and 2Howard Hughes Med Inst, Baltimore, MD, US |
351
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Is There a Harmless Level of Plasma Viremia in Untreated HIV Infection? CD4+ T Cells in the Long-term Follow-up of Elite Controllers and Controls
Hans-Jurgen Stellbrink*1, K Schewe1, C Hoffmann1, and E Wolf2
1IPM Study Ctr, Hamburg, Germany and 2MUC Res, Munich, Germany |
352
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HIV-1 Proviral Load in Elite Suppressors with Low or Declining CD4 Counts
J Deayton1,2, Katherine Groves*1, D Bibby2, H Dreja1, K Aubin1, C DeSouza2, J Hand2, D Clark2, C Orkin2, and A McKnight1
1Queen Mary Sch of Med and Dentistry, London, UK and 2Barts and the London NHS Trust, UK |
353
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Relationship between HIV-specific Immune Response, T Cell Activation, and CD4+ T Cell Depletion in HIV-infected Patients with Undetectable Plasma HIV RNA Levels in the Absence of Therapy
Peter Hunt*1, E Sinclair1, H Hatano1, J McCune1, B Emu1, Q Tan1, P Norris2, M Busch2, J Martin1, and S Deeks1
1Univ of California, San Francisco, US and 2Blood Systems Res Inst, San Francisco, CA, US |
354
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The Role of APOBEC3G/F-mediated Hypermutation in the Control of HIV-1 in Elite Suppressors
Shiv Gandhi*1, J Siliciano1, J Bailey1, R Siliciano1,2, and J Blankson1
1Johns Hopkins Univ Sch of Med, Baltimore, MD, US and 2Howard Hughes Med Inst, Chevy Chase, MD, US |
| 355 |
Polyfunctional HIV-specific T Cells in Rectal Mucosa of HIV Controllers
April Ferre*1, P Hunt2, D Young1, J Garcia1, H Yee2, R Pollard1, S Deeks2, and B Shacklett1
1Univ of California, Davis, US and 2Univ of California, San Francisco, US |
| 356 |
Rare Gag Variants Selected in B*57/5801 HIV-1 Elite Controllers Induce de novo CTL Responses and Reduce Viral Replication Capacity
Toshiyuki Miura*1, M Brockman1, A Schneidewind1, A Raothod1, B Block1, F Pereyra1, T Allen1, M Lobritz2, E Arts2, and B Walker1
1Massachusetts Gen Hosp, Boston, US and 2Case Western Reserve Univ, Cleveland, OH, US |
357
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The HLA-B*5701 Allele Is Highly Enriched in Brazilian Elite Controllers
Maria Teresa Maidana Giret*1, E Bermudez-Aza1, H Tomiyama1, M Melillo Sauer1, D Watkins2, and E Kallas1,3
1Federal Univ of Sao Paulo, Brazil; 2Univ of Wisconsin, US; and 3Univ of Sao Paulo, Brazil |
358
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Regain of Viremic Control after Superinfection of an Elite Controller of HIV-1 Infection
Andrea Rachinger*1, M Navis1, P Groeneveld2, A Van't Wout1, and H Schuitemaker1
1Sanquin Res and Academic Med Ctr, Univ of Amsterdam, The Netherlands and 2Isala Clin, Zwolle, The Netherlands |
359
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Increased Expression of KIR3DL1 Subtypes and HLA-B57 in HIV-exposed Uninfected vs HIV-susceptible Individuals
Salix Boulet*1, M Kleyman1, J Kim1, P Kamya1, S Sharafi1, C Tsoukas1, J Bruneau2, J P Routy1, and N Bernard1
1Res Inst of the McGill Univ Hlth Ctr, Montreal, Canada and 2Ctr Hosp Univ Montreal, Canada |
360
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Prevalence and Characterization of HIV-Specific Adaptive Immune Responses in Genital Mucosal Secretions from a Cohort of High Heterosexual Risk, Seronegative Women in Chicago
Richard Novak*1, L Baum2, P Graham1, H Chen1, W Yang1, and B Parekh3
1Univ of Illinois at Chicago, US; 2Rush Univ, Chicago, IL, US; and 3CDC, Atlanta, GA, US |
| 361a |
Stronger Memory and Lower Effector T Cell Responses to HIV in Patients with Long-term Undetectable HIV Viral Loads under Sustained ART Compared to HIV Controllers
Amelie Guihot*1,2, G Breton3, R Tubiana2, B Amellal4, A G Marcelin4, D Costagliola5, A Samri1, C Katlama2, B Autran1, G Carcelain1, and ALT-ANRS CO 15 study group and DECAMUNE study group
1Hosp Pitie-Salpetriere, Paris, France; 2Hosp Pitie-Salpetriere, Paris, France; 3Hosp Pitie-Salpetriere, Paris, France; 4Hosp Pitie-Salpetriere, Paris, France; and 5INSERM UMR S720, Paris, France |
| 361b |
HIV-1 Gag-specific T cells in Semen but Not in Peripheral Blood of HIV High-risk Seronegative Men
Yan Ding*, G Diaz, J Czartoski, J Lee, H Zhu, T Zhu, and J McElrath
Fred Hutchinson Cancer Res Ctr, Univ of Washington, Seattle, US |
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