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Session 153  Poster Abstracts
Lypoatrophy/Lipohypertrophy: Predictors and Interventions
Monday, 1-4 pm
Room: Hall B
      935 Clinical Associations of Extremity Fat Loss: ACTG 5142, a Prospective, Randomized, Phase III Trial of NRTI-, PI-, and NNRTI-sparing Regimens for ART of Naive, HIV-1-infected Subjects
Richard Haubrich*1, S Riddler2, G DiRienzo3, Y Zheng3, W Powderly4, K Garren5, D Butcher6, J Rooney7, J Mellors2, D Havlir8, and the AIDS Clinical Trials Group 5142 Study Team
1Univ of California, San Diego, US; 2Univ of Pittsburgh, PA, US; 3Harvard Sch of Publ Hlth, Statistical and Data Analysis Ctr, Boston, MA, US; 4Univ Coll Dublin, Ireland; 5Abbott Labs, Abbott Park, IL, US; 6Bristol-Myers Squibb, Plainsboro, NJ, US; 7Gilead Sci, Foster City, CA, US; and 8Univ of California, San Francisco, US
      936

Chromium Supplementation Decreases Insulin Resistance and Trunk Fat
E Aghdassi, Irving Salit*, S Mohammed, B Arendt, and J Allard
Univ Hlth Network, Toronto, Canada
      937

ZDV/3TC/LPV/r, but Not NVP/LPV/r, Is Associated with Limb Fat Loss and Relative Abdominal Fat Accumulation after 24 Months in ATT-naïve HIV-1-infected Men: MEDICLAS, a Randomized Clinical Trial
Marit GA van Vonderen*1, M van Agtmael1, E Hassink2, A Milinkovic3, K Brinkman4, S Geerlings5, M Ristola6, A van Eeden7, S Danner1, P Reiss5, and the MEDICLAS study group
1VU Univ Med Ctr, Amsterdam, The Netherlands; 2Intl Antiviral Therapy Evaluation Ctr, Amsterdam, The Netherlands; 3Hosp Clin, Barcelona, Spain; 4Onze Lieve Vrouwe Gasthuis, Amsterdam, the Netherlands; 5Academic Med Ctr, Univ of Amsterdam, The Netherlands; 6Helsinki Univ Central Hosp, Finland; and 7Medisch Centrum Jan van Goyen, Amsterdam, the Netherlands
      938

Switching from Combivir to Truvada Preserves Limb Fat: Results of a DEXA Sub-Study of a 48-Week Randomized Study
Graeme Moyle*1, M Fisher2, and SWEET Study Group
1Chelsea and Westminster Hosp, London, UK and 2Brighton and Sussex Univ Hosp, Brighton, UK
      939

Influence of NRTI Choice and Efavirenz vs Lopinavir Treatment Options on Lipoatrophy-associated Adipose Tissue Toxicity: A Longitudinal Study
E Hammond, B McKinnon, C Pace, D Nolan, and Simon Mallal*
Murdoch Univ, and Royal Perth Hosp, Australia
      940

Changes in Body Composition Attributable to Lamivudine, Stavudine, Zidovudine, and Abacavir in HIV-infected Persons Initiating ART
Judith Shlay*1, S Sharma2, G Bartsch2, G Peng2, C Gibert3, C Grunfeld4, and the CPCRA and INSIGHT.
1Denver CPCRA, Denver Publ Hlth, CO, US; 2Univ of Minnesota, Minneapolis, US; 3Wide-Reaching AIDS Prgm, VAMC and George Washington Univ, Washington, DC, US; and 4VAMC and Univ of California, San Francisco, US
      941

How Much Fat Loss Is Needed for Lipoatrophy to Become Clinically Evident?
Daniel Podzamczer*1, E Ferrer1, E Martinez2, L del Rio3, I Ruiz1, J Rosales3, E Ribera4, P Barrufet5, J Llibre6, M Aranda7, and the ABCDE Study Team
1Hosp Univ de Bellvitge, Barcelona, Spain; 2Hosp Clin, Barcelona, Spain; 3CETIR, Barcelona, Spain; 4Hosp Vall d`Hebron, Barcelona, Spain; 5Hosp de Mataro, Barcelona, Spain; 6Hosp Germans Trials i Pujol, Badalona, Spain; and 7Hosp de Terrassa, Barcelona, Spain
      942

Relationship of NRTI-mediated Mitochondrial DNA Depletion and Respiratory Chain Activity in Primary Human Subcutaneous Adipocytes
Metodi Stankov*, R Schmidt, G Behrens, and The German Competence Network HIV/AIDS
Hannover Med Sch, Germany
      943

Data on 52-Week Safety and Efficacy of Tesamorelin, a Growth Hormone-releasing Factor Analogue, in HIV-infected Patients with Abdominal Fat Accumulation
J Falutz1, S Allas2, J C Mamputu2, D Kotler3, M Somero4, D Berger5, S Brown6, G Richmond7, J Fessel8, and Steven Grinspoon*9
1Montreal Gen Hosp, McGill Univ Hlth Ctr,Canada; 2Theratechnologies Inc, Montreal, Canada; 3St Luke`s Roosevelt Hosp Ctr, Columbia Univ Coll of Physicians and Surgeons, New York, NY, US; 4Palm Springs, CA, US; 5Northstar Hlth Care, Chicago, IL, US; 6AIDS Res Alliance, West Hollywood, CA, US; 7Broward Gen Med Ctr, Fort Lauderdale, FL, US; 8Kaiser Fndn Res Inst, CA, US; and 9Massachusetts Gen Hosp, Harvard Med Sch, Boston, US
      944

Effects of Diet and Exercise and Rosiglitazone on Body Composition and Lipids, including Oxidized LDL in HIV+ and HIV- Men and Women
David Mun*1, E Engelson1,2, J Albu1,2, M Sharma2, T Pitea2, and D Kotler1,2
1Columbia Univ Coll of Physicians and Surgeons, New York, NY, US and 2St Luke`s Roosevelt Hosp Ctr, New York, NY, US
      945

Relationship between Polymerase Gamma Polymorphisms and ART-induced Lipodystrophy in HIV-infected Patients: A Case-Control Study
Franck Chiappini*, E Teicher, D Vittecoq, and A Lemoine
Hosp Paul Brousse, Villejuif, France
      946

Lipoatrophy and Lipohypertrophy Are Independently Associated with Hypertension: The Effect of Lipoatrophy but not Lipohypertrophy on Hypertension Is Independent of Obesity
Heidi Crane*1, C Grunfeld2, R Harrington1, and M Kitahata1
1Univ of Washington, Seattle, US and 2Univ of California, San Francisco, US
      947

Incidence of Lipodystrophy and Metabolic Syndrome after the Initiation of Combined ART in Sub-Saharan cART-naive Patients
Serge Eholie*1, K Lacombe2,3,4, L Denoeud4, C Adje1, F Cao4, O Bouchaud5, L Slama6, R Landmann7, E Bissagnene1, and P M Girard3,4
1Hosp de Treichville, Abidjan, Côte d`Ivoire; 2INSERM UMR S707, Paris, France; 3Univ Pierre and Marie Curie, Paris, France; 4Hosp St Antoine, Paris, France; 5Hosp Avicenne, Bobigny, France; 6Hosp Tenon, Paris, France; and 7Hosp Bichat, Paris, France
      948 Evaluation of Pregnancy PBMC and Placental MtDNA in HIV-infected, HAART-treated Women, Compared to HIV-uninfected Women
Helene Cote*1,2, E Maan3, E Papp1, T Chaworth-Musters3, I Gadawski1, J van Schalkwyk3, M Jitratkosol3, J Forbes3, D Burdge3, D Money2,3, and The HIV Perinatal Study Group
1Univ of British Columbia, Vancouver, Canada; 2Women`s Hlth Res Inst, Vancouver, Canada; and 3Children`s and Women`s Hlth Ctr of BC, Vancouver, Canada