Session 21 - CROI 2009

Session 21 Oral Abstracts
HIV—Host Interactions
Tuesday, 10-11:45 am
Room: Room 511

10:00 am 75	Emergence of Immune Escape Mutations on Multiple HIV-1 Genomes in Early Infection Avoids Genetic Bottlenecks and Promotes Viral Diversity Mary Kearney*¹, W Shao^1,2, F Maldarelli¹, E Daar³, J Margolick⁴, S Palmer^1,5, J Mellors⁶, and J Coffin⁷ ¹HIV Drug Resistance Prgm, NCI, Frederick, MD, US; ²Advanced Biomed Computing Ctr, SAIC, Frederick, MD, US; ³Los Angeles Biomed Res Inst at Harbor-Univ of California, Los Angeles Med Ctr, US; ⁴Johns Hopkins Univ Bloomberg Sch of Publ Hlth, Baltimore, MD, US; ⁵Swedish Inst for Infectious Disease Control, Karolinska Inst, Stockholm; ⁶Univ of Pittsburgh, PA, US; and ⁷Tufts Univ, Boston, MA, US
10:15 am 76	Single Genome Analysis of HIV-1 Envelope Sequences from Peripheral Blood Mononuclear Cells and Gastrointestinal Lymphoid Tissue Reveals Absence of Viral Evolution during Suppressive ART Teresa Evering*, S Mehandru, M Poles, D Garmon, H Mohri, A Figueroa, D Castor, and M Markowitz Aaron Diamond AIDS Res Ctr, The Rockefeller Univ, New York, NY, US
10:30 am 77	Single Genome Sequence Analysis of Plasma Viruses from HIV-1 Controllers Suggests Ongoing Low-level Replication Helene Mens*^1,2, M Kearney¹, A Wiegand¹, W Shao¹, J Gerstoft³, K Schønning², J Mellors⁴, F Maldarelli¹, T Benfield², and J Coffin^1,5 ¹HIV Drug Resistance Prgm, NCI, Frederick, MD, US; ²Hvidovre Univ Hosp of Copenhagen, Denmark; ³Rigshosp, Copenhagen, Denmark; ⁴Univ of Pittsburgh, PA, US; and ⁵Tufts Univ, Boston, MA, US
10:45 am 78	Perturbation of Human Th17 Cells in HIV Infection Alka Khaitan*, A Elhed Kozhaya, N Manel, L Kozhaya, D Daskalakis, F Valentine, D Littman, and D Unutmaz New York Univ Sch of Med, NY, US
11:00 am 79	CD4 Depletion during Multi-tropic SIV Infection of Sooty Mangabeys Does Not Induce Immune Activation or Simian AIDS J Milush¹, Kiran Mir*², J Brenchley³, J Reeves⁴, K Cole⁵, S Gordon⁶, G Silvestri⁶, and D Sodora² ¹Univ of California, San Francisco, US; ²Seattle Biomed Res Inst, WA, US; ³NIAID, NIH, Bethesda, MD, US; ⁴Monogram Biosci, South San Francisco, CA, US; ⁵Univ of Pittsburgh, PA, US; and ⁶Univ of Pennsylvania, Philadelphia, US
11:15 am 80	SIV_cpz is Pathogenic in Its Natural Host Rebecca Rudicell*¹, J Holland Jones², A Pusey³, K Terio⁴, J Estes⁵, J Raphael⁶, E Lonsdorf⁷, M Wilson³, B Keele¹, and B Hahn¹ ¹Univ of Alabama at Birmingham, US; ²Stanford Univ, CA, US; ³Univ of Minnesota, St Paul, US; ⁴Univ of Illinois, Maywood, US; ⁵NCI-Frederick, MD, US; ⁶Gombe Stream Res Ctr, Kigoma, Tanzania; and ⁷Lincoln Park Zoo, Chicago, IL, US
11:30 am 81LB	AIDS Progression Is Associated with the Emergence of Interleukin-17 Producing NKT Cells Early after SIV Infection Laure Campillo-Gimenez*¹, M-C Cumont², M Fay³, O Diop⁴, M Muller-Trutwin², J Zaunders⁵, M Dy⁶, M Leite-de-Moraes⁶, C Elbim⁷, and J Estaquier¹ ¹INSERM U841, Faculty of Med of Creteil, France; ²Pasteur Inst, Paris, France; ³Faculty of Med, Univ Paris 7 Denis Diderot, France; ⁴Pasteur Inst, Dakar, Senegal; ⁵St Vincent`s Hosp, Darlinghurst, Australia; ⁶Faculty of Med, Paris V Rene Descartes, Hosp Necker, France; and ⁷Univ of Pierre and Marie Curie and Univ Paris Descartes, France