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Session 25
Poster Discussion
Themed Discussion: Sanctuary Sites and Intracellular Pharmacokinetics of ARV
Tuesday, 2:30-3:30 pm
Room: Room 511 |
702
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Efavirenz and Emtricitabine Concentrations Consistently Exceed Wild-type IC50 in Cerebrospinal Fluid: CHARTER Findings
Brookie Best*1, S Letendre1, E Capparelli1, R Ellis1, S Rossi1, P Koopmans2, I Grant1, and the CHARTER Group
1Univ of California, San Diego, US and 2Radboud Univ Nijmegen Med Ctr, Nijmegen, The Netherlands |
703
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Viral Dynamics and Pharmacokinetics in vivo of Tenofovir Disoproxil Fumarate and Abacavir: Evidence of a Non-additive Antiviral Effect
Miguel Goicoechea*1, S Jain1, C Kemper2, E Daar3, J Tilles4, B Ha5, J Flaherty6, D Richman1, S Louie7, R Haubrich1, and California Collaborative Treatment Group
1Univ of California, San Diego, US; 2Santa Clara Valley Med Ctr, San Jose, CA, US; 3Harbor-Univ of California, Los Angeles Med Ctr, Torrance, US; 4Univ of California, Irvine, US; 5GlaxoSmithKline, Research Triangle Park, NC, US; 6Gilead Sci, Foster City, CA, US; and 7Univ of Southern California, Los Angeles, US |
| 704 |
Accelerator Mass Spectrometry: A New Way to Measure Intracellular NRTI Triphosphates
J Chen1, M Seymour2, L Lee1, E Fuchs1, W Hubbard1, T Parsons1, G Pakes3, C Fletcher4, C Garner2, and Charles Flexner*1
1Johns Hopkins Univ, Baltimore, MD, US; 2Xceleron Ltd, York, UK; 3GlaxoSmithKline, Research Triangle Park, NC, US; and 4Univ of Colorado Hlth Sci Ctr, Denver, US |
705
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Efavirenz Increases MRP1 Efflux Transporter Function while Darunavir/Ritonavir Inhibits MRP1 Expression in Healthy Volunteers
Lawrence Lee*1,2, G Soon1, P Shen1, C Flexner2, and P Pham2
1Natl Univ of Singapore and Natl Hlthcare Group and 2Johns Hopkins Univ, Baltimore, MD, US |
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