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Session 28  Poster Discussion
Themed Discussion: Immunologic Mechanisms and Clinical Features of IRIS
Tuesday, 2:30-3:30 pm
Room: Room 517b-d
      771

M. tuberculosis-associated Immune Reconstitution Inflammatory Syndrome Results in Modulation of the Innate Immune Compartment in the Absence of Generalized T Cell Activation
L Montaner1, F Conradie2, L Heine2, D Glencross2, D Lawrie2, W Stevens2, E Papasavvas1, V Maino3, I Sanne2, and Livio Azzoni*1
1Wistar Inst, Philadelphia, PA, US; 2Univ of the Witwatersrand, Johannesburg, South Africa; and 3BD Biosci, San Jose, CA, US
      772 TB-associated Immune Restoration Syndrome in HIV-1-infected Patients Involves Tuberculin-specific CD4 Th1 Cells and Can Be Predicted by KIR-negative gd T Cells
Anne Bourgarit*1, G Carcelain1, A Samri1, C Parizot1, M Lafaurie2, S Abgrall3, V Delcey4, E Vicaut4, D Sereni2, B Autran1, and ANRS EP21 PARADOX-TB Study Group
1INSERM U543, Pitié-Salpetriere Hospital, Paris, France; 2Hosp St Louis, Paris, France; 3Hosp Avicenne, Bobigny, France; and 4Ctr Hosp Univ Lariboisière, Paris, France
      773

Cytokine Profiles Predict Unmasking TB Immune Reconstitution Inflammatory Syndrome, and Are Associated with Unmasking and Paradoxical Presentations of TB Immune Reconstitution Inflammatory Syndrome
Lewis Haddow*1, P Borrow2, O Dibben2, Y Moosa3, and P Easterbrook1
1King`s Coll London, UK; 2Univ of Oxford, UK; and 3Univ of KwaZulu-Natal, Durban, South Africa
      774

Inflammatory Biomarkers in Serum Predict HIV Immune Reconstitution Inflammatory Syndrome and Death after Cryptococcal Meningitis
David Boulware*1, D Meya2, T Bergemann1, B Shuli1, A Kambugu2, E Janoff3, and P Bohjanen1
1Univ of Minnesota, Minneapolis, US; 2Infectious Disease Inst, Kampala, Uganda; and 3Univ of Colorado, Denver, US
      775

Risk Factor Analyses for Immune Reconstitution Inflammatory Syndrome and Mortality during a Randomized Trial of Early versus Deferred ART in the Setting of Acute Opportunistic Infections: ACTG A5164
Philip Grant*1, L Komarow2, I Sereti3, S Pahwa4, M Lederman5, W Powderly6, F Sattler7, P Sax2, J Andersen2, and A Zolopa1
1Stanford Univ, CA, US; 2Harvard Univ, Cambridge, MA, US; 3NIH, Bethesda, MD, US; 4Univ of Miami, FL, US; 5Case Western Reserve Univ, Cleveland, OH, US; 6Univ Coll Dublin, Ireland; and 7Univ of Southern California, Los Angeles, US