Session 11 - CROI 2010

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Session 11-Oral Abstracts
What’s New in Immunopathogenesis
Wednesday, 9:30-11:45 am; Room 2005

9:30 am 41	Dramatic Changes in Fc-Receptor Expression during HIV-1 Infection Associated with Reduced Phagocytic Activity during Progressive HIV-1 Infection Anne-Sophie Dugast*, A Tonelli, I Toth, A Piechocka-Trocha, and G Alter Ragon Inst of Massachusetts Gen Hosp, Massachusetts Inst of Tech, and Harvard Univ, Boston, US
9:45 am 42	Evolution of Neutralizing Antibody Responses and Viral Escape Continues until Advanced Infection and Is Associated with Broad Neutralizing Antibody Activity Frederick Hecht*¹, P Phung², T Wrin², W Hartogensis¹, P Bacchetti¹, C Pilcher¹, L Loeb¹, C Petropoulos², and S Deeks¹ ¹Univ of California, San Francisco, US and ²Monogram Biosci, Inc, South San Francisco, CA, US
10:00 am 43LB	Adaptation of HIV-1 Envelope Glycoprotein to Humoral Immunity at a Population Level E Bunnik, Z Euler, M Welkers, M Grijsen, J Prins, and Hanneke Schuitemaker* Academic Med Ctr, Univ of Amsterdam, The Netherlands
10:15 am 44	Damage to Mucosal Integrity Correlates with Increased Microbial Translocation and Loss of NK Cells, and Is Associated with Rapid SIV Disease Progression in Pigtail Macaques Nichole Klatt*¹, L Harris¹, H Sung², B Tabb³, D Morcock³, B Lafont¹, A Levine², G Alter⁴, J Estes³, and J Brenchley¹ ¹NIAID, NIH, Bethesda, MD, US; ²Case Western Reserve Univ Sch of Med, Cleveland, OH, US; ³AIDS and Cancer Virus Prgm, SAIC-Frederick, NCI-Frederick, MD, US; and ⁴Partners AIDS Res Ctr, Massachusetts Gen Hosp, Harvard Med Sch, Boston, US
10:30 am 45	Interleukin-21 Immune-mediated Control of HIV-1 by HIV-1-specific CD8 T Cells LaTonya Williams*, A Zajac, and P Goepfert Univ of Alabama at Birmingham, US
10:45 am 46LB	Antiviral Suppressive Capacity of CD8⁺ T Cells ex vivo Is Strongly Associated with the Rate of CD4 Cell Loss in Chronic HIV-1 Infection H Yang¹, G Hancock¹, G Clutton¹, N Sande², B Angus¹, J Birks¹, A McMichael¹, and Lucy Dorrell*¹ ¹Univ of Oxford, UK and ²Oxford Radcliffe Hosps NHS Trust, UK
11:00 am 47LB	Immune Failure after Suppressive ART: High Level CD4 and CD8 T Cell Activation but Only Memory CD4 Cells Are Cycling Michael Lederman*¹, B Rodriguez¹, B Clagett¹, N Funderburg¹, K Medvik¹, B Gripshover¹, R Kalayjian¹, S Sieg¹, and L Calabrese² ¹Case Western Reserve Univ, Cleveland, OH, US and ²Cleveland Clin, OH, US
11:15 am 48	Systems Biology Approaches to the Understanding of HIV Immunopathogenesis Rafick-Pierre Sekaly*, L Trautmann, and E Haddad Univ of Montreal, Canada