Session 26 - CROI 2010

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Session 26-Oral Abstracts
New Insights into Retroviral Pathogenesis
Thursday, 9:30-11:45 am; Room 2005

9:30 am 93	Plasma Levels of WFDC1/ps20, a Novel Viral Permissivity Factor in CD4 T Lymphocytes, Correlates Directly with CD4 T Cell Count in Chronic HIV-1 Infection Annapurna Vyakarnam*¹, S Kamu Reddy¹, P Laura¹, M Jane¹, T William¹, P Barry¹, J Cason¹, F Pereyra², and B Walker² ¹King’s Coll London, UK and ²Ragon Inst of Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, US
9:45 am 94LB	Tryptophan Catabolism by Indoleamine 2,3-Dioxygenase Alters the Balance between Th17 and Regulatory T Cells in Progressive HIV Disease David Favre*^1,2, J Mold¹, P Hunt¹, B Kanwar¹, P Loke^1,3, L Seu¹, J Barbour¹, F Hecht¹, S Deeks¹, and J McCune¹ ¹Univ of California, San Francisco, US; ²Natl Immune Monitoring Lab, Montreal, Canada; and ³New York Univ, NY, US
10:00 am 95	Sooty Mangabeys CD4⁺ Central Memory T Cells Are Relatively Resistant to CCR5 Expression and SIV Infection: A Key Mechanism for AIDS Resistance? Mirko Paiardini*¹, B Cervasi¹, E Reyes-Aviles¹, C Vinton², A Ortiz¹, S Bosinger¹, J Else³, J Brenchley², and G Silvestri^1,3 ¹Univ of Pennsylvania, Philadelphia, US; ²NIAID, NIH, Bethesda, MD, US; and ³Yerkes Natl Primate Res Ctr, Emory Univ, Atlanta, GA, US
10:15 am 96LB	Identification of a Novel CCR5 Mutation Common in Sooty Mangabeys Indicates that Entry by SIV_smm Occurs through Alternative Entry Pathways in Addition to CCR5 Nadeene Riddick*¹, E Hermann¹, L Loftin¹, M Paiardini¹, G Silvestri^1,2, and R Collman¹ ¹Univ of Pennsylvania, Philadelphia, US and ²Yerkes Natl Primate Res Ctr, Emory Univ, Atlanta, GA, US
10:30 am 97	Differences in HIV Burden throughout the Gut of Patients on Suppressive ART: Implications for HIV Persistence Steven Yukl*¹, S Gianella², Q Li³, E Sinclair⁴, B Hare⁴, A Haase³, M Fischer², K McQuaid¹, D Havlir⁴, J Wong¹, and the PLUS Study Group ¹San Francisco VAMC and Univ of California, San Francisco, US; ²Univ Hosp Zurich, Switzerland; ³Univ of Minnesota, Minneapolis, US; and ⁴San Francisco Gen Hosp and Univ of California, San Francisco, US
10:45 am 98	The Genetic Diversity of HIV-1 in Plasma Persists Despite Suppression with ART Mary Kearney*¹, J Spindler¹, S Yu¹, W Shao², A O’Shea³, C Rehm³, C Poethke¹, J Mellors⁴, J Coffin⁵, and F Maldarelli¹ ¹HIV Drug Resistance Prgm, NCI-Frederick, MD, US; ²Advanced Biomed Computing Ctr, SAIC-Frederick, MD, US; ³Lab of Immunoregulation, NIAID, NIH, Bethesda, MD, US; ⁴Univ of Pittsburgh, PA, US; and ⁵Tufts Univ, Boston, MA, US
11:00 am 99	Population Decline in a Chimpanzee Community with a High Prevalence of SIV_cpz Infection Rebecca Rudicell*¹, J Holland Jones², E Wroblewski³, E Greengrass⁴, S Kamenya⁵, A Mosser⁵, B Keele⁶, A Pusey³, B Hahn¹, and M Wilson³ ¹Univ of Alabama at Birmingham, US; ²Stanford Univ, CA, US; ³Univ of Minnesota, St Paul, US; ⁴Fauna and Flora Intl, Liberia; ⁵Gombe Stream Res Ctr, Kigoma, Tanzania; and ⁶NCI-Frederick, MD, US
11:15 am 100LB	HIV-1 Replication and Immune Dynamics Are Impacted by Raltegravir Intensification of HAART-suppressed Patients M J Buzon¹, M Massanella¹, J Llibre², A Esteve³, M C Puertas¹, S Palmer⁴, M Stevenson⁵, B Clotet^1,2, J Blanco¹, Javier Martinez-Picado*^1,6, and Integral Collaborative Group ¹Fndn irsiCaixa, Badalona, Spain; ²Fndn Lluita contra la SIDA, Badalona, Spain; ³CEEISCAT, Badalona, Spain; ⁴Swedish Inst for Infectious Disease Control, Solna; ⁵Univ of Massachusetts Med Sch, Worcester, US; and ⁶ICREA, Barcelona, Spain
11:30 am 101LB	Raltegravir Intensification in Antiretroviral-treated Patients Exhibiting a Suboptimal CD4⁺ T Cell Response Hiroyu Hatano*¹, T Hayes², V Dahl³, E Sinclair¹, T-H Lee⁴, P Hunt¹, S Palmer³, M Busch⁴, B Shacklett², and S Deeks¹ ¹Univ of California, San Francisco, US; ²Univ of California, Davis, US; ³Karolinska Inst, Solna, Sweden; and ⁴Blood Systems Res Inst, San Francisco, CA, US