Session 40 - CROI 2010

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Session 40-Oral Abstracts
New Insights into Transmission and Acute Infection
Friday, 9:30-11:30 am; Room 2004

9:30 am 134	A Finite Course of ART during Early HIV-1 Infection Modestly Delays Need for Subsequent ART Initiation: ACTG A5217, the SETPOINT Study Christine Hogan*^1,2, V DeGruttola³, E Daar⁴, X Sun³, C Del Rio⁵, S Fiscus⁶, T Frazier⁷, B Hare⁸, M Markowitz⁹, S Little¹⁰, and the A5217 Study Team ¹Med Coll of Wisconsin, Milwaukee, US; ²Columbia Univ, Coll of Physicians and Surgeons, New York, NY, US; ³Harvard Sch of Publ Hlth, Boston, MA, US; ⁴Harbor-UCLA Med Ctr, Torrance, US; ⁵Emory Univ, Atlanta, GA, US; ⁶Univ of North Carolina at Chapel Hill Sch of Med, US; ⁷NIAID, NIH, Bethesda, MD, US; ⁸Univ of California, San Francisco, US; ⁹Aaron Diamond AIDS Res Ctr, The Rockefeller Univ, New York, NY, US; and ¹⁰Univ of California, San Diego, US
9:45 am 135LB	Profound Depletion of HIV-1 Transcriptionally Active PBMC by Early cART during Primary HIV-1 Infection but Not by Treatment during Chronic Infection: Results of the Zurich Primary HIV Infection Study A Schmid, S Gianella, V Von Wyl, K Metzner, A Scherrer, B Niederöst, B Joos, R Weber, M Fischer, and Huldrych Günthard* Univ Hosp Zurich, Univ of Zurich, Switzerland
10:00 am 136	ART and Risk of Heterosexual HIV-1 Transmission in HIV-1 Serodiscordant African Couples: A Multinational Prospective Study Deborah Donnell*¹, J Kiarie², K Thomas³, J Baeten³, J Lingappa³, C Cohen⁴, and C Celum³ ¹Fred Hutchinson Cancer Res Ctr, Seattle, WA, US; ²Univ of Nairobi and Kenyatta Natl Hosp, Kenya; ³Univ of Washington, Seattle, US; and ⁴Univ of California, San Francisco, US
10:15 am 137	Sex and Race Influence Clinical Presentations and Outcomes following Primary HIV-1 Infection Amie Meditz*¹, S MaWhinney¹, A Allshouse¹, M Markowitz², A Collier³, J-P Routy⁴, J Levy⁵, D Cooper⁶, S Little⁷, and E Connick¹ ¹Univ of Colorado Denver, Aurora, US; ²Aaron Diamond AIDS Res Ctr, The Rockefeller Univ, New York, NY, US; ³Univ of Washington, Seattle, US; ⁴McGill Univ Hlth Ctr, Montreal, Canada; ⁵Univ of California, San Francisco, US; ⁶Natl Ctr in HIV Epi and Clin Res, Sydney, Australia; and ⁷Univ of California, San Diego, US
10:30 am 138	HIV-1 Enters in the Seminal Tract by Multiple Mechanisms and in a Cytokine-rich Environment Jeffrey Anderson*¹, L-H Ping¹, O Dibben², C Jabara¹, I Hoffman¹, P Kazembe³, P Borrow², S Fiscus¹, M Cohen¹, and R Swanstrom¹ ¹Univ of North Carolina at Chapel Hill, US; ²The Jenner Inst for Vaccine Res, Compton, UK; and ³Lilongwe Central Hosp, Malawi
10:45 am 139	Neisseria gonorrhoeae Enhances HIV-1 Infection of Primary Resting CD4⁺ T Cells through TLR2 Activation Jian Ding*¹, A Rapista¹, N Teleshova¹, M Klotman¹, G Jarvis², and T Chang¹ ¹Mt Sinai Sch of Med, New York, NY, US and ²VAMC and Univ of California, San Francisco, US
11:00 am 140	Monospecific Expansion of SIV_mac251 during Acute Infection May Mask Multiple Transmitted Virus Variants Revealed during the Chronic Phase Barbara Felber*¹, E-Y Kim², R Pal³, R Desrosiers⁴, S Wolinsky², and G Pavlakis¹ ¹NCI-Frederick, MD, US; ²Northwestern Univ, Chicago, IL, US; ³Advanced Biosci Labs, Inc, Kensington, MD, US; and ⁴New England Primate Res Ctr, Boston, MA, US
11:15 am 141	Lack of Post-peak Decline of Viremia and Accelerated Course of SIV_mac251 Infection in Rhesus Macaques Undergoing an Antibody-mediated CD4⁺ T Cell Depletion Prior to Infection Alexandra Ortiz*¹, N Klatt², J Brenchley², M Davenport³, and G Silvestri^1,4 ¹Univ of Pennsylvania, Philadelphia, US; ²NIAID, NIH, Bethesda, MD, US; ³Univ of New South Wales, Sydney, Australia; and ⁴Emory Univ, Atlanta, GA, US