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Session 41-Oral Abstracts
Virus–Host Interaction: HIV and XMRV
Friday, 9:30 am-12 noon; Room 2011 |
| 9:30 am 142 |
Ancient Evolutionary Changes to Tetherin Shaped Vpu and Nef Functions in HIV-1 Adaption to Humans
Efrem Lim*1,2, H Malik2, and M Emerman2
1Univ of Washington, Seattle, US and 2Fred Hutchinson Cancer Res Ctr, Seattle, WA, US |
| 9:45 am 143 |
Compensatory Genetic Changes Acquired by a nef-deleted Serially Passaged SIV Vaccine Strain Confer Resistance to Tetherin
Ruth Serra-Moreno*, B Jia, and D Evans
Harvard Med Sch, Southborough, MA, US |
| 10:00 am 144 |
HIV-1 Vpu Transmembrane Domain Mutants: Enhancement of Virion-release Correlates with Down-regulation of BST-2, Is Independent of Ion Channel Activity, and Occurs from a Post-endoplasmic Reticulum Compartment
Mark Skasko*1 and J Guatelli1,2
1Univ of California, San Diego, US and 2VA San Diego Hlthcare System, CA, US |
| 10:15 am 145 |
Use of LEDGF/p75 Fusion Proteins to Retarget Lentiviral Integration Outside of Genes
Keshet Ronen*1, R Gijsbers2, S Vets2, N Malani1, J De Rijck2, M McNeely2, F Bushman1, and Z Debyser2
1Univ of Pennsylvania, Philadelphia, US and 2Katholieke Univ Leuven, Belgium |
| 10:30 am 146 |
Direct Cell-to-Cell HIV Transfer Is Insensitive to ART at High Drug Concentrations
Alex Sigal*1, A Del Portillo2, B Chen2, and D Baltimore1
1California Inst of Tech, Pasadena, US and 2Mt Sinai Sch of Med, New York, NY, US |
| 10:45 am 147LB |
Cellular Determinants Required for Infection of XMRV, a Novel Retrovirus Associated with Human Familial Prostate Cancer
S Bhosle1, S Suppiah1, R Arnold1, Y Liang1, J Blackwell1, J Petros1,2, D Liotta1, E Hunter1, R Molinaro1, and Hinh Ly*1
1Emory Univ, Atlanta, GA, US and 2Atlanta VAMC, Decatur, GA, US |
| 11:00 am 148LB |
Host Regulation of XMRV in Prostate Cancer
B Dong and Robert Silverman*
Cleveland Clin, OH, US |
| 11:15 am 149 |
Prevalence of Xenotropic Murine Leukemia Virus in Prostate Cancer
William Switzer*, H Jia, H Q Zheng, S Tang, and W Heneine
CDC, Atlanta, GA, US |
| 11:30 am 150LB |
Organ and Cell Lineage Dissemination of XMRV in Rhesus Macaques during Acute and Chronic Infection
Prachi Sharma*1, S Suppiah2, R Molinaro2, K Rogers1, J Das Gupta3, R Silverman3, J Hackett, Jr4, S Devare4, G Schochetman4, and F Villinger1,2
1Yerkes Natl Primate Res Ctr, Emory Univ, Atlanta, GA, US; 2Emory Univ Sch of Med, Atlanta, GA, US; 3Cleveland Clin, OH, US; and 4Abbott Diagnostics, Abbott Park, IL, US |
| 11:45 am 151 |
XMRV: Examination of Viral Kinetics, Tissue Tropism, and Serological Markers of Infection
X Qiu1, P Swanson1, K-C Luk1, J Das Gupta2, N Onlamoon3, R Silverman2, F Villinger3, S Devare1, G Schochetman1, and John Hackett, Jr*1
1Abbott Diagnostics, Abbott Park, IL, US; 2Cleveland Clin, OH, US; and 3Yerkes Natl Primate Res Ctr, Emory Univ, Atlanta, GA, US |
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