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Session 86-Poster Abstracts Novel Gene Therapy Approaches Wednesday, 2-4 pm; Poster Hall       429 Protection of CD4+ T Cells Derived from Gene-modified Stem Cells Enhances the Immune Response and Promotes Recovery of Non-modified CD4+ T Cells in the SHIV-macaque Model Patrick Younan*1, P Polacino2, O Ho2, B Beard3, G Trobridge4, D Von Laer5, S-L Hu1,2, and H-P Kiem2,3 1Washington Natl Primate Res Ctr, Seattle, US; 2Univ of Washington, Seattle, US; 3Fred Hutchinson Cancer Res Ctr, Seattle, WA, US; 4Washington State Univ, Pullman, US; and 5Innsbruck Med Univ, Austria       430 Genetic Pressure on HIV Exerted by an env Antisense in Gene-modified Patients Rithun Mukherjee*1, P Tebas1, G Binder-Scholl1, D Stein2, B Levine1, E Papasavvas3, L Montaner3, T Rebello4, C June1, and F Bushman1 1Univ of Pennsylvania, Philadelphia, US; 2Albert Einstein Coll of Med, Bronx, NY, US; 3The Wistar Inst, Philadelphia, PA, US; and 4VIRxSYS Corp, Gaithersburg, MD, US       431 tRNA Promoter Cassettes for the Combinatorial Expression of Short Hairpin RNA Directed against HIV-1 Karl Haushalter*1, L Scherer2, A Anderson1, E Putnam1, A Kretsch1, A Lee1, and J Rossi2 1Harvey Mudd Coll, Claremont, CA, US and 2Beckman Res Inst of City of Hope, Duarte, CA, US       432 Modified Trimera Mice as Novel Humanized Mouse Model for HIV Gene Therapy in Acute Infection Andreas Volk*1,2, S Hartmann3, A Muik1,2, C Buchholz3, C Königs4, J Kimpel1, U Dietrich2, and D von Laer1 1Innsbruck Med Univ, Austria; 2Georg-Speyer-Haus, Inst for Biomed Res, Frankfurt, Germany; 3Paul-Ehrlich-Inst, Langen, Germany; and 4Goethe Univ Med Ctr, Frankfurt, Germany       433 A Single Infusion of Zinc Finger Nuclease CCR5 Modified Autologous CD4 T Cells (SB-728-T) Increases CD4 Counts and Leads to Decrease in HIV Proviral Load in an Aviremic HIV-infected Subject Jay Lalezari*1, R Mitsuyasu2, S Wang3, G Lee3, M Giedlin3, W Tang3, K Spratt3, R Surosky3, N Dubois-Stringfellow3, and D Ando3 1Quest Clin Res, San Francisco, CA, US; 2Univ of California, Los Angeles, US; and 3Sangamo BioSci, Richmond, CA, US