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Session 69
Poster Abstracts
Virologic Parameters in NeuroAIDS
Tuesday, 1-4 pm
Room: Hall D |
| 397 |
Tissue-specific Adaptive Changes in R5X4 HIV-1 Env Variants Compartmentalized in Brain and Lymphoid Tissues of Individuals with AIDS
Lachlan Gray*1,2, M Churchill1, D Cowley1,3, J Sterjovski1,3, A Ellett1, N Saksena4, P Poumbourios1, S Wesselingh1,2,3, D Gabuzda5,6, and P Gorry1,2,3
1Burnet Inst, Melbourne, Australia; 2Univ of Melbourne, Australia; 3Monash Univ, Melbourne, Australia; 4Westmead Millenium Inst, Australia; 5Dana-Farber Cancer Inst, Boston, MA, US; and 6Harvard Med Sch, Boston, MA, US |
| 398 |
Low CD4 Dependence and High Avidity for CD4 Determine Macrophage Tropism, Increased Fusogenicity and Reduced Sensitivity to Fusion and Other Entry Inhibitors of HIV-1 Envelope Glycoproteins from Brain Tissue and Brain-derived Isolates
F Rossi, B Querido, D Nimmagadda, S Navas-Martin, and Julio Martin-Garcia*
Drexel Univ Coll of Med, Philadelphia, PA, US |
| 399 |
Bioinformatic Predictors of Co-receptor Usage Underestimate the Frequency of R5X4 HIV-1 in Brain and Other Tissues
Megan Mefford*1,2, P Gorry3, K Kunstman4, S Wolinsky4, and D Gabuzda1,2
1Dana-Farber Cancer Inst, Boston, MA, US; 2Harvard Med Sch, Boston, MA, US; 3Macfarlane Burnet Inst for Med Res and Publ Hlth, Melbourne, Australia; and 4Feinberg Sch of Med, Northwestern Univ, Chicago, IL, US |
| 400 |
Compartmentalization and Evolutionary Dynamics of HIV-1 NEF Sequences in the Brain of 5 Individuals
Tulio de Oliveira*1, S Lamers2, M Salemi3, and M McGrath4
1South African Natl BioInformatics Inst, Univ of Western Cape; 2BioinfoExperts, FL, US; 3Univ of Florida Gainsville, US; and 4Univ of California, San Francisco, US |
| 401 |
Validation of a V3-based Genetic Biomarker of HIV-1 Neurovirulence
Satish Pillai*1,2, W Pasutti1, A McCutchan3, C Marra4, D Clifford5, B Gelman6, D Simpson7, J McArthur8, I Grant3, and J Wong1,2
1VAMC, San Francisco, CA, US; 2Univ of California, San Francisco, US; 3Univ of California, San Diego, US; 4Univ of Washington, Seattle, US; 5Washington Univ, St Louis, MO, US; 6Univ of Texas Med Branch, Galveston, US; 7Mt Sinai Sch of Med, New York, NY, US; and 8Johns Hopkins Univ, Baltimore, MD, US |
| 402 |
Differential Induction of IDO and the Kynurenine Pathway by Neurotropic and Non-Neurotropic Viruses
Apsara Kandanearatchi*1, J Wilkinson1, J Zaunder1, L Pemberton1, S Maddocks2, A Cunningham2, and B Brew1
1Ctr for Immunology, St Vincent`s Hosp, Univ of New South Wales, Sydney, Australia and 2Millenium Inst, Univ of Sydney, Westmead, Australia |
| 403 |
The Neurotrophins NGF, BDNF, and proNGF Induce Enhancement of HIV-1 Replication in Primary Human Macrophages
Thiago Souza*1,2, D Rodrigues1, E Araujo3, C Fontes2, and D Bou-Habib1
1Oswaldo Cruz Fndn, Rio de Janeiro, Brazil; 2Federal Univ of Rio de Janeiro, Brazil; and 3Fluminense Federal Univ, Niteroi, Brazil |
| 404a |
The Spectrum of HIV-1-associated Neurocognitive Diagnoses Represents a Continuum of Circulating HIV DNA Levels
Bruce Shiramizu*1, A Williams2, C Shikuma1, and V Valcour1
1Hawaii AIDS Clinical Res Prgm, John A Burns Sch of Med, Univ of Hawaii, Honolulu, US and 2Kaiser Fndn Hosp, Ctr for Hlth Res, Honolulu, Hawaii, US |
| 404b |
HIV Subtype D Is Associated with a Higher Risk for Dementia than Subtype A in Sub-Saharan Africa
Ned Sacktor*1, N Nakasujja2, M Rezapour1, R Skolasky1, S Musisi2, E Katabira2, K Robertson3, D Clifford4, O Laeyendecker1, and T Quinn1
1Johns Hopkins Univ, Baltimore, MD, US; 2Makerere Univ, Kampala, Uganda; 3Univ of North Carolina at Chapel Hill, US; and 4Washington Univ, St Louis, MO, US |
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